| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3056714 | T | Cardiotoxicity in Canis lupus familiaris (dog) assessed as change in left ventricular contractility at 1.5 to 15 mg/kg, po | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA3056715 | T | Cardiotoxicity in Canis lupus familiaris (dog) assessed as change in ECG at 1.5 to 15 mg/kg, po | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA3056716 | T | Cardiotoxicity in Canis lupus familiaris (dog) assessed as change in heart rate at 1.5 to 15 mg/kg, po | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA3056717 | T | Toxicity in Rattus norvegicus (rat) at 30 mg/kg, po QD for 5 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA3056718 | F | Reduction in mean arterial blood pressure in po dosed normotensive Canis lupus familiaris (dog) | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA3056719 | F | Antagonist activity at ETA receptor in Rattus norvegicus (rat) assessed as inhibition of ET1-induced pressor response at 10 mg/kg, po administered 3 hr post ET1-induction measured up to 12 hr | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA3056720 | F | Antagonist activity at ETA receptor in Rattus norvegicus (rat) assessed as inhibition of ET1-induced pressor response at 0.6 mg/kg, po administered 3 hr post ET1-induction | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA3056721 | F | Antagonist activity at ETA receptor in Rattus norvegicus (rat) assessed as inhibition of ET1-induced pressor response at 0.1 mg/kg, po administered 3 hr post ET1-induction | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA3056722 | B | Selectivity index, ratio of Ki for Homo sapiens (human) ETB receptor to KI for Homo sapiens (human) ETA receptor | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA3056723 | B | Antagonist activity at ETB receptor in Oryctolagus cuniculus (rabbit) pulmonary artery | Oryctolagus cuniculus | 1 | single protein format | Scientific Literature | ||
| 11. | ALA3057239 | B | Antagonist activity at ETA receptor in Rattus norvegicus (rat) aorta assessed as inhibition of Kcl-induced contraction | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
| 12. | ALA3057240 | B | Antagonist activity at ETA receptor in Homo sapiens (human) umbilical artery | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 13. | ALA3057241 | A | Prodrug conversion in Sus scrofa (pig) liver cytosol assessed as (S)-3-(1-(benzo[d][1,3]dioxol-5-yl)-2-(2-methoxy-4-methylphenylsulfonamido)-2-oxoethyl)-1-methyl-1H-indole-6-carboxylic acid formation | Sus scrofa | 1 | tissue-based format | Scientific Literature | ||
| 14. | ALA3057242 | A | Prodrug conversion in Homo sapiens (human) liver cytosol assessed as (S)-3-(1-(benzo[d][1,3]dioxol-5-yl)-2-(2-methoxy-4-methylphenylsulfonamido)-2-oxoethyl)-1-methyl-1H-indole-6-carboxylic acid formation | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 15. | ALA3057243 | A | Prodrug conversion in male Rattus norvegicus (rat) liver cytosol assessed as (S)-3-(1-(benzo[d][1,3]dioxol-5-yl)-2-(2-methoxy-4-methylphenylsulfonamido)-2-oxoethyl)-1-methyl-1H-indole-6-carboxylic acid formation | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 16. | ALA3057244 | A | Half life in Rattus norvegicus (rat) liver microsome at 1 uM | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 17. | ALA3057245 | A | Half life in Canis lupus familiaris (dog) liver microsome at 1 uM | Canis lupus familiaris | 1 | assay format | Scientific Literature | ||
| 18. | ALA3057246 | A | Half life in Homo sapiens (human) liver microsome at 1 uM | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA3057247 | A | Apparent elimination half life in Rattus norvegicus (rat) assessed as (S)-3-(1-(benzo[d][1,3]dioxol-5-yl)-2-(2-methoxy-4-methylphenylsulfonamido)-2-oxoethyl)-1-methyl-1H-indole-6-carboxylic acid level at 2 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA3057248 | A | Drug absorption in Rattus norvegicus (rat) assessed as (S)-3-(1-(benzo[d][1,3]dioxol-5-yl)-2-(2-methoxy-4-methylphenylsulfonamido)-2-oxoethyl)-1-methyl-1H-indole-6-carboxylic acid level at 2 mg/kg | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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