Inhibition of Homo sapiens (human) dihydrofolate reductase using dihydrofolate as substrate incubated for 5 min prior to substrate addition by spectrophotometric assay
Inhibition of Cryptosporidium parvum recombinant DHFR using dihydrofolate as substrate incubated for 5 min prior to substrate addition by spectrophotometric assay
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in interstitial pneumonia at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in host lung congestion at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as megakaryocytes in host spleen at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as extramedullary hematopoiesis in host spleen at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as epethelioid granuloma in host spleen at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as increase in host spleen red pulp at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in host spleen white pulp at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in host spleen necrosis at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as clear lymphocytes in host liver focal granuloma at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as clear mononuclear cells in host liver focal granuloma at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in host liver necrosis at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as multiple deep ridged parasite surface in host peritoneal exudate at 0.25 mg, po administered 48 hr post-infection measured after 3 days by scanning electron microscopic analysis
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as parasite deformity in host peritoneal exudate at 0.25 mg, po administered 48 hr post-infection measured after 3 days by light microscopic analysis
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decreased parasite movement in host peritoneal exudate at 0.25 mg, po administered 48 hr post-infection measured after 3 days by light microscopic analysis
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in Toxoplasma antigen in host serum at 0.25 mg, po administered 48 hr post-infection measured after 3 days by Co-A test relative to control
Antiparasitic activity against Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in tachozyte count in spleen at 0.25 mg, po administered 48 hr post-infection measured after 3 days by Geimsa staining relative to control
Antiparasitic activity against Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in tachozyte count in liver at 0.25 mg, po administered 48 hr post-infection measured after 3 days by Geimsa staining relative to control