# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA660279 | B | Inhibitory activity against Trypanosoma cruzi cathepsin L-like protease (cruzain) was determined using purified recombinant protein | Trypanosoma cruzi | 78 | single protein format | Scientific Literature | ||
2. | ALA3871352 | F | Antileishmanial activity against intracellular amastigote stage of Leishmania donovani MHOM/ET/67/HU3 infected in human THP1 cells assessed as parasite growth measured after 72 hrs by luciferase reporter gene assay | Leishmania donovani | 33 | cell-based format | Scientific Literature | ||
3. | ALA3871353 | T | Cytotoxicity against human THP1 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
4. | ALA3871354 | T | Cytotoxicity against human MRC5 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
5. | ALA3871355 | T | Selectivity index, ratio of EC50 for human MRC5 cells to EC50 for intracellular Leishmania donovani MHOM/ET/67/HU3 amastigotes | 23 | cell-based format | Scientific Literature | |||
6. | ALA4196378 | F | Antitrypanosomal activity against Trypanosoma brucei Lister 427 bloodstream form assessed as parasite growth inhibition at 50 uM after 72 hrs by SYBR Green assay relative to control | Trypanosoma brucei | 28 | organism-based format | Scientific Literature | ||
7. | ALA4196379 | F | Antileishmanial activity against Leishmania infantum amastigote form assessed as parasite growth inhibition at 50 uM after 72 hrs by steady-Glo reagent based assay relative to control | Leishmania infantum | 28 | organism-based format | Scientific Literature | ||
8. | ALA4196380 | F | Antitrypanosomal activity against Trypanosoma cruzi amastigote form infected in human U2OS cells assessed as parasite growth inhibition at 50 uM after 72 hrs relative to control | Trypanosoma cruzi | 42 | organism-based format | Scientific Literature | ||
9. | ALA4196384 | F | Antitrypanosomal activity against Trypanosoma brucei Lister 427 bloodstream form at 10 uM after 72 hrs by resazurin dye-based assay relative to control | Trypanosoma brucei | 28 | organism-based format | Scientific Literature | ||
10. | ALA4196385 | F | Potentiation of methotrexate-induced antitrypanosomal activity against Trypanosoma brucei Lister 427 bloodstream form at 10 uM after 72 hrs by resazurin dye-based assay relative to control | Trypanosoma brucei | 28 | organism-based format | Scientific Literature | ||
11. | ALA4196386 | A | Inhibition of human microsomal CYP1A2 expressed in baculovirus infected BTI-TN-5B1-4 cells at 10 uM incubated for 30 mins by luciferase assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
12. | ALA4196387 | F | Potentiation of methotrexate-induced antitrypanosomal activity against Trypanosoma brucei Lister 427 bloodstream form at 10 uM after 72 hrs by resazurin dye-based assay | Trypanosoma brucei | 28 | organism-based format | Scientific Literature | ||
13. | ALA4196392 | B | Inhibition of human ERG at 10 uM incubated for 2 hrs by fluorescence polarisation assay relative to control | Homo sapiens | 28 | single protein format | Scientific Literature | ||
14. | ALA4196393 | A | Inhibition of human microsomal CYP2C9 expressed in baculovirus infected BTI-TN-5B1-4 cells at 10 uM incubated for 30 mins by luciferase assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
15. | ALA4196394 | A | Inhibition of human microsomal CYP2C19 expressed in baculovirus infected BTI-TN-5B1-4 cells at 10 uM incubated for 30 mins by luciferase assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
16. | ALA4196395 | A | Inhibition of human microsomal CYP2D6 expressed in baculovirus infected BTI-TN-5B1-4 cells at 10 uM incubated for 30 mins by luciferase assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
17. | ALA4196396 | A | Inhibition of human microsomal CYP3A4 expressed in baculovirus infected BTI-TN-5B1-4 cells at 10 uM incubated for 30 mins by luciferase assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
18. | ALA4196397 | A | Inhibition of recombinant full-length human aurora B kinase expressed in baculovirus system at 10 uM using MBP as substrate incubated for 45 mins by ADP-glo kinase assay | Homo sapiens | 28 | assay format | Scientific Literature | ||
19. | ALA4196398 | A | Cytotoxicity against human A549 cells assessed as growth inhibition at 10 uM after 48 hrs by CellTiter-Glo assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
20. | ALA4196399 | A | Cytotoxicity against human WI38 cells assessed as growth inhibition at 10 uM after 48 hrs by CellTiter-Glo assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature |