# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3420628 | Binding | Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-free assay | Homo sapiens | 49 | ALA3414543 | assay format | Scientific Literature | |
2. | ALA3420629 | Binding | Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed by stimulation with A23187 for 10 mins by RP-HPLC based cell based assay | Homo sapiens | 49 | ALA3414543 | cell-based format | Scientific Literature | |
3. | ALA3420867 | Binding | Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pre-incubated for 15 mins followed by stimulation with A23187 for 10 mins by RP-HPLC based cell based assay | Homo sapiens | 49 | ALA3414543 | cell-based format | Scientific Literature | |
4. | ALA3420871 | Binding | Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using PGH2 substrate by RP-HPLC method | Homo sapiens | 50 | ALA3414543 | cell-based format | Scientific Literature | |
5. | ALA3420872 | Binding | Inhibition of 15-LOX-1 in human blood PMNL assessed as remaining activity by measuring 15-HETE synthesis at 10 uM | Homo sapiens | 50 | ALA3414543 | single protein format | Scientific Literature | |
6. | ALA3420874 | Binding | Inhibition of 12-LOX in human blood PMNL assessed as remaining activity by measuring 12-HETE synthesis at 10 uM | Homo sapiens | 50 | ALA3414543 | single protein format | Scientific Literature | |
7. | ALA3420875 | Binding | Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as assessed as remaining PGE2 synthase activity at 10 uM after 15 mins using PGH2 substrate by RP-HPLC method | Homo sapiens | 32 | ALA3414543 | cell-based format | Scientific Literature | |
8. | ALA3074452 | Functional | Antimycobacterial activity against MDR Mycobacterium tuberculosis grown in MGIT liquid medium assessed as growth inhibition measured after 4 weeks by BACTEC method | Mycobacterium tuberculosis | 19 | ALA3044747 | organism-based format | Scientific Literature | |
9. | ALA3074453 | Functional | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv grown in MGIT liquid medium assessed as growth inhibition measured after 4 weeks by BACTEC method | Mycobacterium tuberculosis | 19 | ALA3044747 | organism-based format | Scientific Literature | |
10. | ALA3267157 | Binding | Inhibition of hexa-His-tagged PAI-1 N152H/K156T/Q321L/M356I mutant (unknown origin) expressed in Escherichia coli BL21(DE3) at 100 uM after 10 mins by uPA-based assay | Homo sapiens | 1 | ALA3259521 | assay format | Scientific Literature |