# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2317024 | Binding | Inhibition of AGT in human DU145 cells assessed as potentiation of laromustine-induced cytotoxicity under hypoxic condition at >10 uM treated 4 hrs prior to laromustine treatment measured after 24 hrs by clonogenic assay | Homo sapiens | 1 | ALA2311245 | cell-based format | Scientific Literature | |
2. | ALA2317025 | ADME | Prodrug activation in human DU145 cells assessed as O6-benzylguanine formation under normoxic condition at 50 uM over 3 hrs by HPLC analysis | Homo sapiens | 1 | ALA2311245 | cell-based format | Scientific Literature | |
3. | ALA2317026 | ADME | Prodrug activation in mouse EMT6 cells assessed as O6-benzylguanine formation under normoxic condition at 50 uM after 3 hrs by HPLC analysis | Mus musculus | 1 | ALA2311245 | cell-based format | Scientific Literature | |
4. | ALA2317027 | ADME | Prodrug activation in mouse EMT6 cells assessed as O6-benzylguanine formation under hypoxic condition at 50 uM after 3 hrs by HPLC analysis | Mus musculus | 1 | ALA2311245 | cell-based format | Scientific Literature | |
5. | ALA2317028 | Binding | Inhibition of AGT in human DU145 cells assessed as potentiation of laromustine-induced cytotoxicity under normoxic condition up to 10 uM treated 4 hrs prior to laromustine treatment measured after 24 hrs by clonogenic assay | Homo sapiens | 1 | ALA2311245 | cell-based format | Scientific Literature | |
6. | ALA2317029 | Binding | Inhibition of AGT in human DU145 cells assessed as potentiation of laromustine-induced cytotoxicity under hypoxic condition up to 10 uM treated 4 hrs prior to laromustine treatment measured after 24 hrs by clonogenic assay | Homo sapiens | 1 | ALA2311245 | cell-based format | Scientific Literature | |
7. | ALA2317032 | ADME | Prodrug activation in human DU145 cells assessed as O6-benzylguanine formation under hypoxic condition at 50 uM over 3 hrs by HPLC analysis | Homo sapiens | 1 | ALA2311245 | cell-based format | Scientific Literature |