# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2318162 | F | In vivo antitumor activity against FR-negative mouse 4T1 cells implanted in Balb/c mouse assessed as decrease in tumor volume at 2 umol/kg, iv treated 33 days after implantation for TIW 2 week schedule | Mus musculus | 1 | organism-based format | Scientific Literature | ||
2. | ALA2318163 | F | In vivo antitumor activity against FR-positive human KB cells implanted in Balb/c mouse assessed as decrease in tumor volume at 2 umol/kg, iv treated 33 days after implantation for TIW 2 week schedule in presence of excess folic acid | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
3. | ALA2318164 | F | In vivo antitumor activity against FR-positive mouse M109 cells implanted in Balb/c mouse assessed as decrease in tumor volume at 2 umol/kg, iv treated 33 days after implantation for TIW 3 week schedule | Mus musculus | 2 | organism-based format | Scientific Literature | ||
4. | ALA2318165 | T | Toxicity in FR-positive human KB cells implanted Balb/c mouse assessed as gross toxicity at 2 umol/kg, iv TIW 2 week schedule | Mus musculus | 2 | organism-based format | Scientific Literature | ||
5. | ALA2318166 | A | Half life in FR-positive cells treated Balb/c mouse at 2 umol/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
6. | ALA2318167 | A | Half life in human serum at 37 degC | Homo sapiens | 2 | cell-free format | Scientific Literature | ||
7. | ALA2318168 | A | Binding affinity to human serum albumin assessed as binding rate at 8 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
8. | ALA2318169 | F | Antitumor activity against FR-negative mouse 4T1 cells assessed as decrease in cell viability measured after 48 hrs by MTT proliferation assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
9. | ALA2318170 | F | Antitumor activity against FR-positive human KB cells assessed as decrease in cell viability measured after 48 hrs by MTT proliferation assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
10. | ALA2318171 | F | In vivo antitumor activity against FR-positive human KB cells implanted in Balb/c mouse assessed as decrease in tumor volume at 2 umol/kg, iv treated 33 days after implantation for TIW 2 week schedule | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
11. | ALA2318172 | T | Toxicity in FR-positive human KB cells implanted Balb/c mouse assessed as weight loss at 2 umol/kg, iv TIW 2 week schedule | Mus musculus | 1 | organism-based format | Scientific Literature |