# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2318567 | F | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC27294 assessed as complete cessation of growth | Mycobacterium tuberculosis | 94 | ALA2311418 | organism-based format | Scientific Literature | |
2. | ALA2318568 | A | Cytotoxicity against mouse macrophage cell line J774.1 (ATCC TIB-67) for 3 days by Alamar Blue | Mus musculus | 94 | ALA2311418 | cell-based format | Scientific Literature | |
3. | ALA3606285 | B | Inhibition of Wnt/beta-catenin in human U2OS cells assessed as internalization of frizzled-GFP at 12.5 uM after 6 hrs by confocal microscopic analysis | Homo sapiens | 36 | ALA3603766 | cell-based format | Scientific Literature | |
4. | ALA3606286 | B | Inhibition of Wnt/beta-catenin in HEK293 cells assessed as inhibition of Wnt3A-stimulated TOPFlash activity after 8 hrs | Homo sapiens | 36 | ALA3603766 | cell-based format | Scientific Literature | |
5. | ALA3606287 | B | Inhibition of Wnt/beta-catenin in human HCT116 cells assessed as remaining cytosolic beta-catenin level at 2 uM after 18 hrs by Western blot analysis relative to control | Homo sapiens | 9 | ALA3603766 | cell-based format | Scientific Literature | |
6. | ALA3606289 | F | Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTS assay | Homo sapiens | 7 | ALA3603766 | cell-based format | Scientific Literature | |
7. | ALA3606290 | A | Oral bioavailability in Sprague-Dawley rat at 5 mg/kg | Rattus norvegicus | 3 | ALA3603766 | organism-based format | Scientific Literature | |
8. | ALA3606291 | A | Total clearance in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 3 | ALA3603766 | organism-based format | Scientific Literature | |
9. | ALA3606292 | A | Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 3 | ALA3603766 | organism-based format | Scientific Literature | |
10. | ALA3606293 | A | Half life in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 3 | ALA3603766 | organism-based format | Scientific Literature | |
11. | ALA4404535 | F | Antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation at 10 uM incubated for 7 days by GFP reporter gene assay relative to control | Human adenovirus 5 | 55 | ALA4402567 | organism-based format | Scientific Literature | |
12. | ALA4404536 | F | Antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation incubated for 7 days by GFP reporter gene assay | Human adenovirus 5 | 55 | ALA4402567 | organism-based format | Scientific Literature | |
13. | ALA4404537 | A | Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay | Homo sapiens | 55 | ALA4402567 | cell-based format | Scientific Literature | |
14. | ALA4404538 | T | Selectivity index, ratio of CC50 for cytotoxicity against human A549 cells to IC50 for antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation after 7 days | 55 | ALA4402567 | cell-based format | Scientific Literature | ||
15. | ALA4404539 | F | Antiviral activity against Human adenovirus 5 infected in human A549 cells assessed as inhibition of viral entry at 50 uM after 48 hrs by GFP reporter gene based assay relative to control | Human adenovirus 5 | 10 | ALA4402567 | organism-based format | Scientific Literature | |
16. | ALA4404540 | F | Antiviral activity against Human adenovirus 5 infected in human A549 cells assessed as inhibition of viral entry after 48 hrs by GFP reporter gene based assay | Human adenovirus 5 | 10 | ALA4402567 | organism-based format | Scientific Literature | |
17. | ALA4404543 | F | Antiviral activity against Human adenovirus 5 infected in human A549 cells assessed as fold reduction in virus yield at 10 uM after 48 hrs endpoint dilution method relative to control | Human adenovirus 5 | 1 | ALA4402567 | organism-based format | Scientific Literature | |
18. | ALA4404550 | F | Antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of viral infection at 10 uM measured after 5 to 10 mins post infection by GFP reporter gene assay relative to control | Human adenovirus 5 | 1 | ALA4402567 | organism-based format | Scientific Literature | |
19. | ALA4404557 | F | Antiviral activity against Human adenovirus 5 infected in human A549 cells asssessed as inhibition of viral entry by measuring nuclear-associated viral genome level at 10 uM after 45 mins by RT-PCR analysis (Rvb = 100.24 +/- 2.77%) | Human adenovirus 5 | 1 | ALA4402567 | organism-based format | Scientific Literature | |
20. | ALA4404562 | F | Antiviral activity against Human adenovirus 5 infected in human A549 cells assessed as inhibition of viral DNA replication by measuring number of viral DNA copies at 10 uM after 24 hrs by RT-qPCR analysis (Rvb = 100 +/- 1.55%) | Human adenovirus 5 | 1 | ALA4402567 | organism-based format | Scientific Literature |