| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2318569 | B | Stimulation of alkaline phosphatase activity in mouse calvarial osteoblasts at 1 pM to 1 uM after 48 hrs by spectrophotometric analysis | Mus musculus | 26 | assay format | Scientific Literature | ||
| 2. | ALA2318570 | B | Stimulation of alkaline phosphatase activity in mouse calvarial osteoblasts at 1 pM to 1 uM after 48 hrs by spectrophotometric analysis relative to nifedipine | Mus musculus | 19 | assay format | Scientific Literature | ||
| 3. | ALA2318571 | A | Cytotoxicity against mouse calvarial osteoblasts assessed as cell viability at 1 pM to 1 uM after 48 hrs by MTT assay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA2318572 | F | Induction of mineralization in mouse calvarial osteoblasts assessed as increase of mineralized nodules formation after 21 days by alizarin red-S staining based spectrophotometric analysis | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 5. | ALA2318573 | F | Induction of mineralization in mouse calvarial osteoblasts assessed as increase of mineralized nodules formation at 100 pM after 21 days by alizarin red-S staining based spectrophotometric analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA2318574 | F | Induction of mineralization in mouse calvarial osteoblasts assessed as increase of mineralized nodules formation measuring concentration required for maximum activity after 21 days by alizarin red-S staining based spectrophotometric analysis | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 7. | ALA2318575 | F | Induction of proliferation of mouse calvarial osteoblasts at 1 pM to 1 uM after 48 hrs | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA2318576 | B | Stimulation of alkaline phosphatase activity in mouse calvarial osteoblasts assessed as concentration required for maximum activity after 48 hrs by spectrophotometric analysis | Mus musculus | 22 | assay format | Scientific Literature | ||
| 9. | ALA2318577 | T | Hepatotoxicity against BALB/c mouse assessed as morphological changes at 1 to 10 mg/kg/day, po after 2 months | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA2318578 | F | Induction of new bone formation in ovariectomized BALB/c mouse model assessed as increase in bone formation rate at 10 mg/kg/day, po qd for 8 weeks by bone histomorphometry analysis (Rvb =0.10 um'3/um'2/day) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA2318579 | F | Induction of new bone formation in ovariectomized BALB/c mouse model assessed as increase in bone formation rate at 5 mg/kg/day, po qd for 8 weeks by bone histomorphometry analysis (Rvb =0.10 um'3/um'2/day) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA2318580 | F | Induction of new bone formation in ovariectomized BALB/c mouse model assessed as increase in bone formation rate at 1 mg/kg/day, po qd for 8 weeks by bone histomorphometry analysis (Rvb =0.10 um'3/um'2/day) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA2318581 | F | Induction of new bone formation in ovariectomized BALB/c mouse model assessed as increase in mineral apposition rate at 10 mg/kg/day, po qd for 8 weeks by bone histomorphometry analysis (Rvb =0.11 um/day) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA2318582 | F | Induction of new bone formation in ovariectomized BALB/c mouse model assessed as increase in mineral apposition rate at 5 mg/kg/day, po qd for 8 weeks by bone histomorphometry analysis (Rvb =0.11 um/day) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA2318583 | F | Induction of new bone formation in ovariectomized BALB/c mouse model assessed as increase in mineral apposition rate at 1 mg/kg/day, po qd for 8 weeks by bone histomorphometry analysis (Rvb =0.11 um/day) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA2318584 | F | Inhibition of osteoclastogenesis in ovariectomized BALB/c mouse model assessed as increase in OPG/RANKL ratio at 5 to 10 mg/kg/day, po qd for 8 weeks by qPCR analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA2319483 | F | Inhibition of osteoclastogenesis in ovariectomized BALB/c mouse model assessed as increase in OPG/RANKL ratio at 1 mg/kg/day, po qd for 8 weeks by qPCR analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA2319484 | F | Inhibition of osteoclastogenesis in ovariectomized BALB/c mouse model assessed as suppression of RANK gene expression at 5 to 10 mg/kg/day, po qd for 8 weeks by qPCR analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA2319485 | F | Inhibition of osteoclastogenesis in ovariectomized BALB/c mouse model assessed as suppression of TRAP gene expression at 5 to 10 mg/kg/day, po qd for 8 weeks by qPCR analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA2319486 | F | Inhibition of osteoclastogenesis in ovariectomized BALB/c mouse model assessed as suppression of RANK gene expression at 1 mg/kg/day, po qd for 8 weeks by qPCR analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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