| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2319025 | T | Toxicity in New Zealand white rabbit assessed as CNS effect at plasma concentration of 3 to 4 times 20% change in atrium effective refractory period | Oryctolagus cuniculus | 2 | organism-based format | Scientific Literature | ||
| 2. | ALA2319027 | F | Increase of effective refractory period in New Zealand white rabbit assessed as maximum change in QT interval at 0.1 and 1 umol/kg/min for 15 mins infusions | Oryctolagus cuniculus | 2 | organism-based format | Scientific Literature | ||
| 3. | ALA2319029 | A | Unbound steady state plasma concentration in New Zealand white rabbit assessed as concentration required to 20% change in atrium effective refractory period at 0.1 and 1 umol/kg/min for 15 mins infusions | Oryctolagus cuniculus | 2 | cell-free format | Scientific Literature | ||
| 4. | ALA2319030 | B | Inhibition of IK channel (unknown origin) | Homo sapiens | 23 | single protein format | Scientific Literature | ||
| 5. | ALA2319031 | B | Inhibition of human ERG | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 6. | ALA2319032 | B | Inhibition of human Kv1.5 channel expressed in CHO cells by high throughput planar patch clamp assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 7. | ALA3301365 | A | ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with whole human plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound. | Homo sapiens | 1,614 | cell-free format | AstraZeneca Deposited Data | ||
| 8. | ALA3301369 | A | ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with whole guinea pig plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound. | Cavia porcellus | 91 | cell-free format | AstraZeneca Deposited Data |
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