| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2320107 | B | Positive allosteric modulation of rat muscarinic M5 receptor assessed as acetylcholine response | Rattus norvegicus | 2 | single protein format | Scientific Literature | ||
| 2. | ALA2320108 | F | Positive allosteric modulation of human muscarinic M5 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA2320109 | B | Positive allosteric modulation of rat muscarinic M3 receptor assessed as acetylcholine response | Rattus norvegicus | 2 | single protein format | Scientific Literature | ||
| 4. | ALA2320110 | F | Positive allosteric modulation of human muscarinic M3 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA2320111 | B | Positive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine response relative to control | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
| 6. | ALA2320112 | B | Positive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine response | Rattus norvegicus | 2 | single protein format | Scientific Literature | ||
| 7. | ALA2320113 | F | Positive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA2320114 | F | Positive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA2320115 | B | Positive allosteric modulation of rat muscarinic M1 receptor assessed as acetylcholine response relative to control | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
| 10. | ALA2320116 | B | Positive allosteric modulation of rat muscarinic M1 receptor assessed as acetylcholine response | Rattus norvegicus | 2 | single protein format | Scientific Literature | ||
| 11. | ALA2320117 | F | Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA2320118 | A | Fraction unbound in human plasma | Homo sapiens | 2 | cell-free format | Scientific Literature | ||
| 13. | ALA2320119 | F | Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA2320366 | A | Fraction unbound in rat plasma | Rattus norvegicus | 2 | cell-free format | Scientific Literature | ||
| 15. | ALA2320367 | A | Clearance in rat hepatocytes | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA2320368 | A | Clearance in human hepatocytes | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA2320369 | B | Positive allosteric modulation of rat muscarinic M4 receptor assessed as acetylcholine response at 10 uM relative to acetylcholine | Rattus norvegicus | 2 | single protein format | Scientific Literature | ||
| 18. | ALA2320370 | F | Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response at 10 uM treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay relative to acetylcholine | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA2320371 | B | Positive allosteric modulation of rat muscarinic M4 receptor assessed as acetylcholine response | Rattus norvegicus | 4 | single protein format | Scientific Literature | ||
| 20. | ALA2320372 | F | Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay relative to control | Homo sapiens | 34 | cell-based format | Scientific Literature |
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