# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2320478 | B | Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after 10 to 30 mins by enzyme immunoassay | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
2. | ALA2320727 | F | Inhibition of LTA4H in po dosed Balb/c mouse assessed as concentration required to decrease calcium ionophore-stimulated LTB4 production in blood administered for 4 hrs prior to calcium ionophore challenge measured after 10 to 30 mins by enzyme immunoassay | Mus musculus | 2 | organism-based format | Scientific Literature | ||
3. | ALA2320728 | F | Inhibition of LTA4H in po dosed Balb/c mouse assessed as decrease in calcium ionophore-stimulated LTB4 production in blood administered for 4 hrs prior to calcium ionophore challenge measured after 10 to 30 mins by enzyme immunoassay | Mus musculus | 2 | organism-based format | Scientific Literature | ||
4. | ALA2320729 | A | Half life in Sprague-Dawley rat at 3 mg/kg, iv and 10 mg/kg, po | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
5. | ALA2320730 | A | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
6. | ALA2320731 | A | Clearance in Sprague-Dawley rat at 3 mg/kg, iv and 10 mg/kg, po | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
7. | ALA2320732 | A | Volume of distribution at steady state in Sprague-Dawley rat at 3 mg/kg, iv and 10 mg/kg, po | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
8. | ALA2320733 | B | Inhibition of LTA4H in human whole blood assessed as decrease in LTB4 production | Homo sapiens | 2 | single protein format | Scientific Literature | ||
9. | ALA2320734 | B | Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calcium ionophore challenge measured after 10 to 30 mins by enzyme immunoassay | Mus musculus | 27 | single protein format | Scientific Literature |