# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2320020 | F | Antimitotic activity in human HeLa cells at 100 nM by immunofluorescence-based microscopy | Homo sapiens | 1 | ALA2311402 | cell-based format | Scientific Literature | |
2. | ALA2320889 | B | Inhibition of microtubule assembly in human HeLa cells assessed as absence of microtubule at 50 to 100 nM by immunofluorescence-based microscopy | Homo sapiens | 1 | ALA2311402 | cell-based format | Scientific Literature | |
3. | ALA2320892 | A | Inhibition of human CYP3A4 at 1 uM | Homo sapiens | 4 | ALA2311402 | single protein format | Scientific Literature | |
4. | ALA2320893 | A | Inhibition of human CYP2D6 at 1 uM | Homo sapiens | 4 | ALA2311402 | single protein format | Scientific Literature | |
5. | ALA2320894 | A | Inhibition of human CYP2C9 at 1 uM | Homo sapiens | 4 | ALA2311402 | single protein format | Scientific Literature | |
6. | ALA2320895 | A | Inhibition of human CYP2C19 at 1 uM | Homo sapiens | 4 | ALA2311402 | single protein format | Scientific Literature | |
7. | ALA2320896 | A | Inhibition of human CYP1A2 at 1 uM | Homo sapiens | 4 | ALA2311402 | single protein format | Scientific Literature | |
8. | ALA2320897 | A | Apparent permeability across basolateral to apical side in human Caco2 cells after 2 hrs by LC-MS/MS analysis | Homo sapiens | 4 | ALA2311402 | cell-based format | Scientific Literature | |
9. | ALA2320898 | A | Apparent permeability across apical to basolateral side in human Caco2 cells after 2 hrs by LC-MS/MS analysis | Homo sapiens | 4 | ALA2311402 | cell-based format | Scientific Literature | |
10. | ALA2320899 | P | Solubility of the compound at pH 7.4 after 90 mins by LC/MS-UV analysis | 4 | ALA2311402 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA2320900 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining after 30 mins by LC-MS/MS assay | Mus musculus | 6 | ALA2311402 | microsome format | Scientific Literature | |
12. | ALA2320901 | A | Metabolic stability in human liver microsomes assessed as compound remaining after 30 mins by LC-MS/MS assay | Homo sapiens | 6 | ALA2311402 | microsome format | Scientific Literature | |
13. | ALA2320902 | F | Antitumor activity against human bifocal rhabdomyosarcoma cells xenografted in WAG/Rij rat assessed as vascular disruption at 15 mg/kg, iv after 24 hrs by magnetic resonance imaging analysis | Homo sapiens | 2 | ALA2311402 | organism-based format | Scientific Literature | |
14. | ALA2321138 | F | Antitumor activity against human bifocal rhabdomyosarcoma cells xenografted in WAG/Rij rat assessed as vascular disruption at 15 mg/kg, iv after 1 hr by magnetic resonance imaging analysis | Homo sapiens | 2 | ALA2311402 | organism-based format | Scientific Literature | |
15. | ALA2321140 | F | Induction of apoptosis in human U87MG cells assessed as ROS generation at 100 nM after 1hr by fluorescence plate reader analysis | Homo sapiens | 2 | ALA2311402 | cell-based format | Scientific Literature | |
16. | ALA2321141 | F | Cytotoxicity against human U87MG cells assessed as cell death at 100 nM by trypan blue exclusion assay relative to control | Homo sapiens | 2 | ALA2311402 | cell-based format | Scientific Literature | |
17. | ALA2321142 | F | Cytotoxicity against human U87MG cells assessed as cell survival after 24 hrs by MTS conversion assay | Homo sapiens | 2 | ALA2311402 | cell-based format | Scientific Literature | |
18. | ALA2321144 | F | Induction of apoptosis in human U87MG assessed as reduction in mitochondrial membrane potential at 100 nM after 24 hrs by JC-1 staining-based fluorescence microscopy | Homo sapiens | 2 | ALA2311402 | cell membrane format | Scientific Literature | |
19. | ALA2321145 | F | Induction of apoptosis in human HeLa cells assessed as necrotic cells by annexin V-FITC/ propidium iodide staining-based flow cytometry | Homo sapiens | 2 | ALA2311402 | cell-based format | Scientific Literature | |
20. | ALA2321146 | F | Induction of apoptosis in human HeLa cells at 100 nM by annexinV-FITC-based flow cytometry | Homo sapiens | 2 | ALA2311402 | cell-based format | Scientific Literature |