| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2317527 | B | Selectivity ratio of IC50 for N-terminal His6-tagged human TNKS1 (1091 to 1325 amino acid residues) to IC50 for PARP2 (unknown origin) | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 2. | ALA2317528 | B | Inhibition of Tankyrase in human HEK293 cells assessed as inhibition of Wnt pathway by Wnt3a-induced STF assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA2317529 | B | Inhibition of PARP2 (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 4. | ALA2317530 | B | Inhibition of N-terminal His6-tagged human TNKS2 (946 to 1162 amino acid residues) after 60 mins by autoparsylation assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 5. | ALA2317531 | B | Inhibition of N-terminal His6-tagged human TNKS1 (1091 to 1325 amino acid residues) after 60 mins by autoparsylation assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 6. | ALA3111839 | A | Solubility in fasted state simulated intestinal fluid at pH 6.8 | 12 | assay format | Scientific Literature | |||
| 7. | ALA3111840 | A | Half life in CD-1 mouse plasma at 1 uM by LC-MS/MS analysis | Mus musculus | 16 | cell-free format | Scientific Literature | ||
| 8. | ALA3111842 | B | Inhibition of TNKS in human SW480 cells assessed as degradation of total pool of beta-catenin after 40 to 48 hrs | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
| 9. | ALA3111843 | B | Inhibition of 6x-His-tagged TNKS1 (unknown origin) after 60 mins | Homo sapiens | 36 | single protein format | Scientific Literature | ||
| 10. | ALA3111846 | A | Volume of distribution at steady state in rat at 5 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA3111847 | A | Half life in rat at 5 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA3111848 | A | Clearance in rat at 5 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA3111849 | A | AUC (infinity) in rat at 5 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA5227342 | B | Inhibition of human TNKS1 (1030 to 1317 residues) measured after 20 hrs | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 15. | ALA5227343 | B | Inhibition of human TNKS2 (873 to 1162 residues) measured after 15 hrs in presence of NAD+ by fluorescence assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 16. | ALA5227346 | B | Inhibition of TBC (unknown origin) | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 17. | ALA5227348 | P | Half life of compound in PBS buffer | 2 | small-molecule physicochemical format | Scientific Literature |
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