| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2318659 | F | Antihypertensive activity in mouse assessed as effect on phenylephrine-induced vasopressor activity at 5 mg/kg, sc administered 2 hrs prior to phenylephrine-challenge | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA2318660 | F | Antihypertensive activity in mouse assessed as sulprostone-induced mean arterial pressure at 5 mg/kg, sc administered 2 hr prior to sulprostone-challenge (Rvb = 53.3 +/- 2.3 mmHg) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA2318661 | F | Antihypertensive activity in mouse assessed as 17PTPGE2-induced mean arterial pressure at 5 mg/kg, sc administered 2 hr prior to 17PTPGE2-challenge (Rvb = 50.3 +/- 5.5 mmHg) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA2318662 | A | AUC in mouse at 5 mg/kg, sc | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA2318663 | A | Fraction unbound in mouse plasma | Mus musculus | 3 | cell-free format | Scientific Literature | ||
| 6. | ALA2318664 | A | Drug metabolism in mouse liver microsomes assessed as cytochrome P450-mediated benzylic oxidation | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 7. | ALA2320390 | A | Drug metabolism in mouse liver microsomes assessed as cytochrome P450-mediated methylene linker oxidation | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 8. | ALA2320392 | A | Drug metabolism in mouse liver microsomes assessed as esterase-mediated sulfonamide hydrolysis | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 9. | ALA2320393 | A | Intrinsic clearance in mouse liver microsomes | Mus musculus | 7 | microsome format | Scientific Literature | ||
| 10. | ALA2320400 | B | Antagonist activity at mouse TP receptor | Mus musculus | 15 | single protein format | Scientific Literature | ||
| 11. | ALA2320401 | B | Antagonist activity at mouse EP4 receptor | Mus musculus | 15 | single protein format | Scientific Literature | ||
| 12. | ALA2320402 | B | Antagonist activity at mouse EP2 receptor | Mus musculus | 15 | single protein format | Scientific Literature | ||
| 13. | ALA2320403 | B | Antagonist activity at mouse EP3 receptor | Mus musculus | 15 | single protein format | Scientific Literature | ||
| 14. | ALA2320404 | F | Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx | Mus musculus | 14 | cell-based format | Scientific Literature | ||
| 15. | ALA2320644 | A | Cmax in mouse at 5 mg/kg, sc | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA2320645 | A | Tmax in mouse at 5 mg/kg, sc | Mus musculus | 1 | organism-based format | Scientific Literature |
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