# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2321398 | F | Cytotoxicity against human multiple myeloma RPMI8226 measured after 24 to 48 hrs by MTT assay | Homo sapiens | 5 | ALA2311274 | cell-based format | Scientific Literature | |
2. | ALA2321399 | B | Inhibition of recombinant GGTase 2 (unknown origin) by scintillation counting in presence of [3H]GGPP | Homo sapiens | 6 | ALA2311274 | assay format | Scientific Literature | |
3. | ALA3266742 | B | Inhibition of GGDPS in human RPMI-8226 cells assessed as disruption of Rap1a geranylgeranylation at 10 uM after 48 hrs by western blot analysis | Homo sapiens | 6 | ALA3259705 | cell-based format | Scientific Literature | |
4. | ALA3266743 | B | Inhibition of GGDPS in human RPMI-8226 cells assessed as disruption of Rab6 geranylgeranylation at 10 uM after 48 hrs by western blot analysis | Homo sapiens | 5 | ALA3259705 | cell-based format | Scientific Literature | |
5. | ALA3266744 | B | Inhibition of FDPS in human RPMI-8226 cells assessed as disruption of Ras farnesylation after 48 hrs by western blot analysis | Homo sapiens | 6 | ALA3259705 | cell-based format | Scientific Literature | |
6. | ALA3268700 | B | Inhibition of GGDPS in human RPMI-8226 cells assessed as decrease in intracellular GGPP level by measuring GGTase-1-mediated GGPP incorporation into fluorescent GCVLL peptide at 1 uM after 24 hrs by reverse phase HPLC analysis | Homo sapiens | 3 | ALA3259705 | cell-based format | Scientific Literature | |
7. | ALA3268701 | B | Inhibition of GGDPS in human RPMI-8226 cells assessed as increase in intracellular FPP level by measuring FTase-1-mediated FPP incorporation into fluorescent GCVLS peptide at 1 uM after 24 hrs by reverse phase HPLC analysis | Homo sapiens | 3 | ALA3259705 | cell-based format | Scientific Literature | |
8. | ALA3268702 | B | Inhibition of recombinant GGDPS (unknown origin) assessed as decrease in radiolabeld GGPP level using FPP and [14C]IPP as substrate treated with enzyme for 10 mins prior to substrate challenge for 30 mins by liquid scintillation counting analysis | Homo sapiens | 6 | ALA3259705 | single protein format | Scientific Literature | |
9. | ALA3268703 | B | Inhibition of recombinant FDPS (unknown origin) assessed as decrease in radiolabeld GGPP level using GPP and [14C]IPP as substrate treated with enzyme for 10 mins prior to substrate challenge for 30 mins by liquid scintillation counting analysis | Homo sapiens | 5 | ALA3259705 | single protein format | Scientific Literature | |
10. | ALA3268704 | B | Inhibition of recombinant FTase (unknown origin) assessed as decrease in prenylated fluorescent peptides level using dansyl-GCVLS and FPP as substrate after 1 hr by HPLC-fluorescence detection analysis | Homo sapiens | 5 | ALA3259705 | protein complex format | Scientific Literature | |
11. | ALA3268705 | B | Inhibition of recombinant GGTase 1 (unknown origin) assessed as decrease in prenylated fluorescent peptides level using dansyl-GCVLS and GGPP as substrate after 1 hr by HPLC-fluorescence detection analysis | Homo sapiens | 5 | ALA3259705 | assay format | Scientific Literature | |
12. | ALA3268706 | B | Inhibition of recombinant GGTase 2 (unknown origin) using recombinant Rab1A and [3H]GGPP as substrate after 20 mins by liquid scintillation counting analysis in presence of recombinant REP-2 | Homo sapiens | 5 | ALA3259705 | assay format | Scientific Literature | |
13. | ALA3268707 | B | Inhibition of GGDPS in human RPMI-8226 cells assessed as disruption of monoclonal protein trafficking by measuring accumulation of intracellular lambda light chain at 10 uM after 48 hrs by ELISA | Homo sapiens | 4 | ALA3259705 | cell-based format | Scientific Literature | |
14. | ALA4182961 | B | Inhibition of GGDPS in human RPMI8266 cells assessed as decrease in Rab GTPase geranylgeranylation by measuring accumulation of intracellular lambda light chain at 50 to 1000 nM after 48 hrs by ELISA | Homo sapiens | 1 | ALA4177743 | cell-based format | Scientific Literature | |
15. | ALA4182962 | B | Inhibition of GGDPS in human RPMI8266 cells assessed as increase in Rap1a level at 50 to 1000 nM after 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA4177743 | cell-based format | Scientific Literature |