| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2317560 | B | Inhibition of I-domain of human integrin alphaL (amino acid residues 128 to 307) plus initial methionine K287C/K294C mutant-ICAM1 interaction expressed in BL21 cells after 4 hrs by surface plasmon resonance analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA2317561 | B | Binding affinity to I-domain of human integrin alphaL (amino acid residues 128 to 307) plus initial methionine K287C/K294C mutant expressed in BL21 cells by NMR spectroscopy | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA2317562 | B | Binding affinity to I-domain of human integrin alphaL (amino acid residues 128 to 307) plus initial methionine expressed in Escherichia coli by NMR spectroscopy | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 4. | ALA2317567 | F | Inhibition of VEGF production in mouse B16 M cells at 10 ug/ml preincubated for 30 mins prior to H2O2 addition measured after 2 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA2317568 | F | Inhibition of VEGF production in mouse B16 M cells at 10 ug/ml preincubated for 30 mins prior to ICAM addition measured after 2 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA2317569 | B | Inhibition of LFA-1/ICAM-1 interaction in human peripheral blood leukocytes assessed as reduction on PMA-induced adhesion to immobilized human recombinant ICAM-1 at 20 ug/ 5 x 10'5 cells after 30 mins by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA2317570 | F | Antimetastatic activity against mouse CT26 cells allografted in BALB/c mouse assessed as decrease in cancer cell volume in liver at 10 ug/ml preincubated for 30 mins prior to inoculation measured on day 14 relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA2317571 | F | Antimetastatic activity against mouse CT26 cells allografted in BALB/c mouse assessed as reduction in metastasis density at 10 ug/ml preincubated for 30 mins prior to inoculation measured on day 14 relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA2317572 | B | Inhibition of LFA-1/ICAM-1 interaction in mouse Lim51b cells assessed as PMA-induced adhesion to ICAM-1 expressing HSE cells measured per 10'5 cells after 30 mins by fluorometric microplate reader analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA2317573 | B | Inhibition of LFA-1/ICAM-1 interaction in mouse Lim51b cells assessed as PMA-induced adhesion to ICAM-1 expressing HSE cells at 20 ug/ 5 x 10'5 cells after 30 mins by fluorometric microplate reader analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA2317574 | B | Inhibition of VLA-4/VCAM-1 interaction in mouse B16M cells assessed as PMA-induced adhesion to immobilized VCAM-1 at 25 ug/ 5 x 10'5 cells after 30 mins by microplate reader analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA2317575 | B | Inhibition of LFA-1/ICAM-1 interaction in mouse CT26 cells assessed as PMA-induced adhesion to ICAM-1 expressing HSE cells at 20 ug/ 5 x 10'5 cells by fluorometric microplate reader analysis | Mus musculus | 11 | cell-based format | Scientific Literature |
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