| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2329585 | F | Antihypertensive activity in telemetered hypertensive double-transgenic rat model expressing human renin and angiotensinogen assessed as reduction of mean arterial blood pressure at 30 mg/kg, po | Rattus norvegicus | 1 | ALA2321871 | organism-based format | Scientific Literature | |
| 2. | ALA2329586 | F | Antihypertensive activity in telemetered hypertensive double-transgenic rat model expressing human renin angiotensinogen assessed as time required for 50 % recovery at 30 mg/kg, po | Rattus norvegicus | 1 | ALA2321871 | organism-based format | Scientific Literature | |
| 3. | ALA2329587 | F | Antihypertensive activity in telemetered hypertensive double-transgenic rat model expressing human renin angiotensinogen assessed as time required for 50 % recovery at 6 mg/kg, po | Rattus norvegicus | 1 | ALA2321871 | organism-based format | Scientific Literature | |
| 4. | ALA2329588 | F | Antihypertensive activity in po dosed telemetered hypertensive double-transgenic rat model expressing human renin and angiotensinogen assessed as reduction of mean arterial blood pressure | Rattus norvegicus | 1 | ALA2321871 | organism-based format | Scientific Literature | |
| 5. | ALA2329589 | A | AUC (0 to 24 hrs) in Sprague-Dawley rat at 6 mg/kg, po by HPLC analysis | Rattus norvegicus | 1 | ALA2321871 | organism-based format | Scientific Literature | |
| 6. | ALA2329590 | A | Cmax in Sprague-Dawley rat at 6 mg/kg, po by HPLC analysis | Rattus norvegicus | 1 | ALA2321871 | organism-based format | Scientific Literature | |
| 7. | ALA2329591 | A | Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv and 6 mg/kg, po by HPLC analysis | Rattus norvegicus | 1 | ALA2321871 | organism-based format | Scientific Literature | |
| 8. | ALA2329592 | A | Plasma clearance in Sprague-Dawley rat at 2 mg/kg, iv and 6 mg/kg, po by HPLC analysis | Rattus norvegicus | 1 | ALA2321871 | organism-based format | Scientific Literature | |
| 9. | ALA2329593 | A | Half life in Sprague-Dawley rat at 2 mg/kg, iv and 6 mg/kg, po by HPLC analysis | Rattus norvegicus | 1 | ALA2321871 | organism-based format | Scientific Literature | |
| 10. | ALA2329594 | A | Oral bioavailability in Sprague-Dawley rat at 6 mg/kg by HPLC analysis | Rattus norvegicus | 1 | ALA2321871 | organism-based format | Scientific Literature | |
| 11. | ALA2329595 | A | Time dependent inhibition of CYP3A4 (unknown origin) | Homo sapiens | 1 | ALA2321871 | single protein format | Scientific Literature | |
| 12. | ALA2329596 | B | Inhibition of human recombinant BACE2 expressed in baculovirus-infected SF9 cells using fluorescence-quenched RE(EDANS)-EVNLDAEF-K(DABSYL)-R as substrate incubated for 1 hr prior to substrate addition measured after 1 hr by fluorescence polarization assay | Homo sapiens | 1 | ALA2321871 | cell-based format | Scientific Literature | |
| 13. | ALA2329597 | B | Inhibition of human recombinant BACE1 expressed in baculovirus-infected SF9 cells using fluorescence-quenched RE(EDANS)-EVNLDAEF-K(DABSYL)-R as substrate incubated for 1 hr prior to substrate addition measured after 1 hr by fluorescence polarization assay | Homo sapiens | 1 | ALA2321871 | cell-based format | Scientific Literature | |
| 14. | ALA2329598 | B | Inhibition of human recombinant cathepsin E expressed in Escherichia coli using fluorescence-quenched Ac-E-D(EDANS)-KPILFFRLG-K(Dabcyl)-E-Amid as substrate incubated for 1 hr prior to substrate addition measured after 1 hr by fluorescence polarization assay | Homo sapiens | 1 | ALA2321871 | assay format | Scientific Literature | |
| 15. | ALA2329599 | B | Inhibition of human recombinant cathepsin D expressed in baculovirus-infected SF9 cells using fluorescence-quenched Ac-E-D(EDANS)-KPILFFRLG-K(Dabcyl)-E-Amid as substrate incubated for 1 hr prior to substrate addition measured after 1 hr by fluorescence polarization assay | Homo sapiens | 1 | ALA2321871 | cell-based format | Scientific Literature | |
| 16. | ALA2329600 | B | Inhibition of human recombinant pepsin C expressed in Escherichia coli using fluorescence-quenched Dabcyl-E-R-Nle-F-L-S-F-P-EDANS as substrate incubated for 1 hr prior to substrate addition measured after 1 hr by fluorescence polarization assay | Homo sapiens | 1 | ALA2321871 | assay format | Scientific Literature | |
| 17. | ALA2329601 | B | Inhibition of human recombinant pepsin A expressed in Escherichia coli using fluorescence-quenched Dabcyl-E-R-Nle-F-L-S-F-P-EDANS as substrate incubated for 1 hr prior to substrate addition measured after 1 hr by fluorescence polarization assay | Homo sapiens | 1 | ALA2321871 | assay format | Scientific Literature | |
| 18. | ALA2327101 | B | Inhibition of human recombinant renin using fluorescence-quenched (RE(EDANS)IHPFHLVIHTK(Dabcyl)R as substrate incubated for 1 hr prior to substrate addition measured after 1 hr by fluorescence polarization assay | Homo sapiens | 8 | ALA2321871 | single protein format | Scientific Literature | |
| 19. | ALA2327103 | B | Inhibition of human plasma renin | Homo sapiens | 1 | ALA2321871 | single protein format | Scientific Literature | |
| 20. | ALA2327104 | F | Antihypertensive activity in telemetered hypertensive double-transgenic rat model expressing human renin and angiotensinogen assessed as reduction of mean arterial blood pressure at 6 mg/kg, po | Rattus norvegicus | 1 | ALA2321871 | organism-based format | Scientific Literature |
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