#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA2328822	A	Oral bioavailability in rat at 50 mg/kg	Rattus norvegicus	1		organism-based format	Scientific Literature
2.	ALA2328823	A	Half life in rat at 50 mg/kg, po	Rattus norvegicus	1		organism-based format	Scientific Literature
3.	ALA2328824	A	AUC in rat at 50 mg/kg, po	Rattus norvegicus	1		organism-based format	Scientific Literature
4.	ALA2328825	A	Half life in rat at 1 mg/kg, iv	Rattus norvegicus	1		organism-based format	Scientific Literature
5.	ALA2328826	A	AUC in rat at 1 mg/kg, iv	Rattus norvegicus	1		organism-based format	Scientific Literature
6.	ALA2328827	A	Clearance in rat at 1 mg/kg, iv	Rattus norvegicus	1		organism-based format	Scientific Literature
7.	ALA2328828	A	Volume of distribution in rat at 1 mg/kg, iv	Rattus norvegicus	1		organism-based format	Scientific Literature
8.	ALA2328945	F	Inhibition of FASN in Sprague-Dawley rat assessed as reduction of de novo synthesis of palmitate at 50 mg/kg, po relative to control	Rattus norvegicus	1		organism-based format	Scientific Literature
9.	ALA2328946	F	Inhibition of FASN in Sprague-Dawley rat assessed as reduction of de novo synthesis of palmitate at 15 mg/kg, po relative to control	Rattus norvegicus	1		organism-based format	Scientific Literature
10.	ALA2328947	A	Drug level in Sprague-Dawley rat liver at 50 mg/kg, po after 8 hrs	Rattus norvegicus	1		organism-based format	Scientific Literature
11.	ALA2328948	A	Drug level in Sprague-Dawley rat liver at 15 mg/kg, po after 8 hrs	Rattus norvegicus	1		organism-based format	Scientific Literature
12.	ALA2328949	B	Inhibition of FASN in rat NMU cells assessed as reduction of de novo synthesis of palmitate	Rattus norvegicus	1		cell-based format	Scientific Literature
13.	ALA2328950	B	Inhibition of FASN in human HeLa cells assessed as reduction of de novo synthesis of palmitate	Homo sapiens	1		cell-based format	Scientific Literature
14.	ALA2328951	A	Cytotoxicity against human HuH7 cells after 72 hrs by celltiter glo assay	Homo sapiens	13		cell-based format	Scientific Literature
15.	ALA2328952	U	Selectivity index, ratio of CC50 for human HuH7 cells to EC50 for HCV1b		12		cell-based format	Scientific Literature
16.	ALA2328955	F	Antiviral activity against HCV1b infected in human HuH7 cells assessed as inhibition of viral RNA replication after 72 hrs by luciferase reporter gene assay	Hepacivirus hominis	19		organism-based format	Scientific Literature
17.	ALA2328956	B	Inhibition of rat FASN assessed as release of co-enzyme A	Rattus norvegicus	21		single protein format	Scientific Literature
18.	ALA2328957	B	Inhibition of human FASN assessed as release of co-enzyme A	Homo sapiens	21		single protein format	Scientific Literature
19.	ALA3705868	B	Biochemical Assay: The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FASN comprises about 25% of the cytosolic proteins in this cell line. SKBr3 cells were homogenized in a dounce homogenizer then centrifuged for 15 minutes at 4C. to remove particulate matter. The supernatant was then analyzed for protein content, diluted to the appropriate concentration, and used to measure FASN activity. The presence of FASN was confirmed by western blot analysis. A similar method for isolation of FASN from SKBr3 cells is described in Teresa, P. et al. (Clin. Cancer Res. 2009; 15(24), 7608-7615).FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) released during the fatty acid synthase reaction. The dye CPM (7-diethylamino-3-(4â-maleimidyl-phenyl)-4-methylcoumarin) contains a thiol reactive group that increases its fluorescence emission.		472		cell-based format	BindingDB Database