| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2330852 | B | Inhibition of alpha-1 adrenoceptor (unknown origin) | Homo sapiens | 1 | ALA2321868 | assay format | Scientific Literature | |
| 2. | ALA2330853 | A | Plasma clearance in Sprague-Dawley rat at 2 mg/kg, iv by HPLC-MS analysis | Rattus norvegicus | 1 | ALA2321868 | organism-based format | Scientific Literature | |
| 3. | ALA2330854 | F | Antihypertensive activity in double transgenic rat overexpressing human renin and angiotensinogen assessed as reduction in mean arterial pressure at 6 to 30 mg/kg, po after 12 hrs | Rattus norvegicus | 1 | ALA2321868 | organism-based format | Scientific Literature | |
| 4. | ALA2330855 | F | Antihypertensive activity in double transgenic rat overexpressing human renin and human angiotensinogen assessed as reduction in mean arterial pressure at 30 mg/kg, po | Rattus norvegicus | 1 | ALA2321868 | organism-based format | Scientific Literature | |
| 5. | ALA2330856 | F | Antihypertensive activity in po dosed double transgenic rat overexpressing human renin and human angiotensinogen assessed as reduction in mean arterial pressure | Rattus norvegicus | 1 | ALA2321868 | organism-based format | Scientific Literature | |
| 6. | ALA2330857 | A | AUC (0 to 24 hrs) in jugular vein cannulated Sprague-Dawley rat at 6 mg/kg, po by HPLC-MS analysis | Rattus norvegicus | 1 | ALA2321868 | organism-based format | Scientific Literature | |
| 7. | ALA2330858 | A | Cmax in jugular vein cannulated Sprague-Dawley rat at 6 mg/kg, po by HPLC-MS analysis | Rattus norvegicus | 1 | ALA2321868 | organism-based format | Scientific Literature | |
| 8. | ALA2330859 | A | Volume of distribution at steady state in jugular vein cannulated Sprague-Dawley rat at 2 mg/kg, iv by HPLC-MS analysis | Rattus norvegicus | 1 | ALA2321868 | organism-based format | Scientific Literature | |
| 9. | ALA2330860 | A | Oral bioavailability in jugular vein cannulated Sprague-Dawley rat at 6 mg/kg by HPLC-MS analysis | Rattus norvegicus | 1 | ALA2321868 | organism-based format | Scientific Literature | |
| 10. | ALA2330861 | A | Half life in jugular vein cannulated Sprague-Dawley rat at 2 mg/kg, iv by HPLC-MS analysis | Rattus norvegicus | 1 | ALA2321868 | organism-based format | Scientific Literature | |
| 11. | ALA2330862 | B | Inhibition of human ERG by dofetilide binding assay | Homo sapiens | 1 | ALA2321868 | single protein format | Scientific Literature | |
| 12. | ALA2330863 | B | Inhibition of 5-HT2B (unknown origin) | Homo sapiens | 1 | ALA2321868 | single protein format | Scientific Literature | |
| 13. | ALA2330864 | B | Inhibition of 5-HT2A (unknown origin) | Homo sapiens | 1 | ALA2321868 | single protein format | Scientific Literature | |
| 14. | ALA2330865 | B | Inhibition of 5-HT1A (unknown origin) | Homo sapiens | 1 | ALA2321868 | single protein format | Scientific Literature | |
| 15. | ALA2330866 | B | Inhibition of human recombinant BACE-2 expressed in baculovirus-infected insect sf9 cells using RE( EDANS)-EVNLDAEF-K(DABSYL)-R as substrate incubated for 1 hr prior to substrate addition measured after 1 hr by FRET-based enzymatic assay | Homo sapiens | 1 | ALA2321868 | cell-based format | Scientific Literature | |
| 16. | ALA2330920 | B | Inhibition of human recombinant BACE-1 expressed in baculovirus-infected insect sf9 cells using RE( EDANS)-EVNLDAEF-K(DABSYL)-R as substrate incubated for 1 hr prior to substrate addition measured after 1 hr by FRET-based enzymatic assay | Homo sapiens | 1 | ALA2321868 | cell-based format | Scientific Literature | |
| 17. | ALA2330921 | B | Inhibition of renin in human plasma using RE(EDANS)IHPFHLVIHTK(Dabcyl)R as substrate incubated for 1 hr prior to substrate addition measured after 2 hrs by FRET-based enzymatic assay | Homo sapiens | 1 | ALA2321868 | single protein format | Scientific Literature | |
| 18. | ALA2330922 | B | Inhibition of human recombinant pepsin C expressed in Escherichia coli using Dabcyl-E-R-Nle-F-L-S-F-P-EDANS as substrate incubated for 1 hr prior to substrate addition measured after 1 hr by FRET-based enzymatic assay | Homo sapiens | 2 | ALA2321868 | assay format | Scientific Literature | |
| 19. | ALA2330923 | B | Inhibition of human recombinant pepsin A expressed in Escherichia coli using Dabcyl-E-R-Nle-F-L-S-F-P-EDANS as substrate incubated for 1 hr prior to substrate addition measured after 1 hr by FRET-based enzymatic assay | Homo sapiens | 2 | ALA2321868 | assay format | Scientific Literature | |
| 20. | ALA2330924 | B | Inhibition of human recombinant cathepsin-E expressed in Escherichia coli using Ac- E-D(EDANS)-KPILFFRLG-K(Dabcyl)-E-Amid as substrate incubated for 1 hr prior to substrate addition measured after 1 hr by FRET-based enzymatic assay | Homo sapiens | 2 | ALA2321868 | assay format | Scientific Literature |
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