| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2327919 | B | Antiprion activity against scrapie prion protein (unknown origin) infected in mouse ScGT1 cells assessed as decrease in PrPSc accumulation after 5 days measured following PK digestion by Western blot analysis | Not specified | 4 | cell-based format | Scientific Literature | ||
| 2. | ALA2327922 | A | Cytotoxicity against mouse ScGT1 cells assessed as cell viability at EC50 concentration after 5 days by fluorescence plate reader analysis | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 3. | ALA2327923 | A | Cytotoxicity against mouse ScGT1 cells assessed as cell viability at 10 uM after 5 days by fluorescence plate reader analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA2327924 | B | Antiprion activity against scrapie prion protein (unknown origin) infected in mouse ScGT1 cells assessed as inhibition of PrPSc replication by ELISA | Not specified | 5 | cell-based format | Scientific Literature | ||
| 5. | ALA2327925 | A | Cytotoxicity against mouse ScGT1 cells assessed as cell viability at 1 uM after 5 days by fluorescence plate reader analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA2328048 | B | Inhibition of mouse PrP (23-230) fibril formation assessed as extension of lag phase at 50 uM by amyloid seeding assay (Rvb = 50 hrs) | Mus musculus | 3 | single protein format | Scientific Literature | ||
| 7. | ALA2328050 | B | Binding affinity to pre-aggregated amyloid beta (1 to 42) (unknown origin) at 25 nM by Thioflavin T-based fluorometric assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA2328051 | B | Displacement of Thioflavin-T from pre-aggregated amyloid beta (1 to 42) (unknown origin) at >25 nM by fluorometric assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA2328052 | B | Binding affinity to pre-aggregated amyloid beta (1 to 42) (unknown origin) assessed as hyperchromic effect at 5 uM by fluorescence analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA2328053 | B | Inhibition of amyloid beta (1 to 42) (unknown origin) fibril formation at 1:1 compound to amyloid beta ratio after 24 hrs by Thioflavin T-based fluorometric assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 11. | ALA2328054 | A | Permeability of the compound assessed as diffusion from donor plate through porcine brain lipid membrane into acceptor plate at pH 7.4 by PAMPA method | 3 | assay format | Scientific Literature | |||
| 12. | ALA5140814 | B | Inhibition of amyloid beta (unknown origin) measured by ThT-based fluorimetric assay | Homo sapiens | 1 | assay format | Scientific Literature |
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