# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2330751 | Toxicity | Toxicity in ferret assessed as induction of stereotypical behavior at 1 to 30 mg/kg, sc measured for 60 mins | Mustela putorius furo | 1 | ALA2321838 | organism-based format | Scientific Literature | |
2. | ALA2330752 | Toxicity | Toxicity in ferret assessed as induction of emetic episodes at 1 to 30 mg/kg, sc measured for 60 mins | Mustela putorius furo | 1 | ALA2321838 | organism-based format | Scientific Literature | |
3. | ALA2330753 | Functional | Reduction of alcohol intake in alcohol-preferring rat at 1 mg/kg, sc after 24 hrs | Rattus norvegicus | 1 | ALA2321838 | organism-based format | Scientific Literature | |
4. | ALA2330754 | Functional | Reduction of alcohol intake in alcohol-preferring rat at 3 mg/kg, sc after 6 to 24 hrs | Rattus norvegicus | 1 | ALA2321838 | organism-based format | Scientific Literature | |
5. | ALA2330755 | Functional | Reduction of alcohol intake in alcohol-preferring rat at 0.33 mg/kg, sc after 2 to 24 hrs | Rattus norvegicus | 1 | ALA2321838 | organism-based format | Scientific Literature | |
6. | ALA2330756 | Binding | Desensitization of rat alpha3beta4 nACHR expressed in HEK293 cells assessed as inhibition of 86Rb+ efflux preincubated for 10 mins measured after 2 hrs by liquid scintillation counting analysis | Rattus norvegicus | 9 | ALA2321838 | cell-based format | Scientific Literature | |
7. | ALA2330757 | Functional | Reduction of alcohol intake in sc dosed alcohol-preferring rat after 2 to 24 hrs relative to vehicle-treated control | Rattus norvegicus | 1 | ALA2321838 | organism-based format | Scientific Literature | |
8. | ALA2330759 | Binding | Agonist activity at rat alpha3beta4 nACHR expressed in HEK293 cells assessed as stimulation of 86Rb+ efflux after 2 hrs by liquid scintillation counting analysis | Rattus norvegicus | 9 | ALA2321838 | cell-based format | Scientific Literature | |
9. | ALA2330760 | Binding | Desensitization of human alpha4beta2 nACHR expressed in HEK293 cells assessed as inhibition of 86Rb+ efflux preincubated for 10 mins measured after 2 hrs by liquid scintillation counting analysis | Homo sapiens | 9 | ALA2321838 | cell-based format | Scientific Literature | |
10. | ALA2330761 | Binding | Agonist activity at human alpha4beta2 nACHR expressed in HEK293 cells assessed as stimulation of 86Rb+ efflux after 2 hrs by liquid scintillation counting analysis relative to nicotine | Homo sapiens | 6 | ALA2321838 | cell-based format | Scientific Literature | |
11. | ALA2330762 | Binding | Agonist activity at human alpha4beta2 nACHR expressed in HEK293 cells assessed as stimulation of 86Rb+ efflux after 2 hrs by liquid scintillation counting analysis | Homo sapiens | 9 | ALA2321838 | cell-based format | Scientific Literature | |
12. | ALA2330763 | Binding | Selectivity ratio of Ki for rat alpha7 nACHR to rat alpha4beta2 nACHR | Rattus norvegicus | 11 | ALA2321838 | assay format | Scientific Literature | |
13. | ALA2330764 | Binding | Selectivity ratio of Ki for rat alpha3beta4 nACHR to rat alpha4beta2 nACHR | Rattus norvegicus | 11 | ALA2321838 | assay format | Scientific Literature | |
14. | ALA2330765 | Binding | Displacement of [3H]-Epibatidine from rat nACHR fore-brain by liquid scintillation counting analysis | Rattus norvegicus | 12 | ALA2321838 | assay format | Scientific Literature | |
15. | ALA2330766 | Binding | Displacement of [3H]-Epibatidine from rat alpha7 nACHR expressed in HEK293 cell membranes by liquid scintillation counting analysis | Rattus norvegicus | 12 | ALA2321838 | cell membrane format | Scientific Literature | |
16. | ALA2330767 | Binding | Displacement of [3H]-Epibatidine from rat alpha4beta4 nACHR expressed in HEK293 cell membranes by liquid scintillation counting analysis | Rattus norvegicus | 12 | ALA2321838 | cell membrane format | Scientific Literature | |
17. | ALA2330768 | Binding | Displacement of [3H]-Epibatidine from rat alpha4beta2 nACHR expressed in HEK293 cell membranes by liquid scintillation counting analysis | Rattus norvegicus | 12 | ALA2321838 | cell membrane format | Scientific Literature | |
18. | ALA2330769 | Binding | Displacement of [3H]-Epibatidine from rat alpha3beta4 nACHR expressed in HEK293 cell membranes by liquid scintillation counting analysis | Rattus norvegicus | 12 | ALA2321838 | cell membrane format | Scientific Literature | |
19. | ALA2330770 | Binding | Displacement of [3H]-Epibatidine from rat alpha3beta2 nACHR expressed in HEK293 cell membranes by liquid scintillation counting analysis | Rattus norvegicus | 12 | ALA2321838 | cell membrane format | Scientific Literature | |
20. | ALA2330771 | Binding | Displacement of [3H]-Epibatidine from rat alpha2beta4 nACHR expressed in HEK293 cell membranes by liquid scintillation counting analysis | Rattus norvegicus | 12 | ALA2321838 | cell membrane format | Scientific Literature |