# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2329649 | F | Antidiabetic activity in streptzotocin-induced-diabetic Wistar rat model assessed as AUC (0 to 1 hr) of plasma glucose level at 0.3 mg/kg, po by oral liquid meal tolerance test | Rattus norvegicus | 2 | ALA2321755 | organism-based format | Scientific Literature | |
2. | ALA2329651 | A | Metabolic stability in rat intestinal microsomes assessed as compound remaining at 50 uM after 60 mins | Rattus norvegicus | 3 | ALA2321755 | microsome format | Scientific Literature | |
3. | ALA2329652 | F | Antidiabetic activity in streptzotocin-induced-diabetic Wistar rat model assessed as AUC (0 to 1 hr) of plasma glucose level at 1 mg/kg, po by oral liquid meal tolerance test | Rattus norvegicus | 3 | ALA2321755 | organism-based format | Scientific Literature | |
4. | ALA2329653 | B | Selectivity ratio of IC50 for rat SGLT2 to IC50 for rat SGLT1 | Rattus norvegicus | 3 | ALA2321755 | assay format | Scientific Literature | |
5. | ALA2329654 | A | Metabolic stability in rat intestinal microsomes assessed as compound remaining at 50 uM after 30 mins | Rattus norvegicus | 3 | ALA2321755 | microsome format | Scientific Literature | |
6. | ALA2329655 | B | Inhibition of rat SGLT1 | Rattus norvegicus | 3 | ALA2321755 | single protein format | Scientific Literature | |
7. | ALA2329656 | B | Inhibition of rat SGLT2 | Rattus norvegicus | 3 | ALA2321755 | single protein format | Scientific Literature | |
8. | ALA2329661 | B | Inhibition of human SGLT2 expressed in COS7 cells assessed as inhibition [14C]-AMG cellular uptake | Homo sapiens | 29 | ALA2321755 | cell-based format | Scientific Literature | |
9. | ALA2329662 | B | Selectivity ratio of IC50 for human SGLT2 to IC50 for human SGLT1 | Homo sapiens | 29 | ALA2321755 | assay format | Scientific Literature | |
10. | ALA2329663 | B | Inhibition of human SGLT1 expressed in COS7 cells assessed as inhibition [14C]-AMG cellular uptake | Homo sapiens | 29 | ALA2321755 | cell-based format | Scientific Literature |