| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2329507 | F | Decrease in lung/body weight ratio in GSK1016790A-induced Sprague-Dawley rat pulmonary edema model at 10 mg/kg, iv administered 30 mins prior to GSK-1016790A injection | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA2329508 | F | Decrease in lung/body weight ratio in GSK1016790A-induced Sprague-Dawley rat pulmonary edema model at 3 mg/kg, iv administered 30 mins prior to GSK-1016790A injection | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA2329509 | A | Effect on mean arterial pressure in Sprague-Dawley rat at 3 to 10 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA2329510 | F | Reduction of GSK-1016790A-induced decrease in mean arterial pressure in iv dosed Sprague-Dawley rat administered 30 mins prior to GSK-1016790A injection | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA2329511 | A | Fraction unbound in rat plasma | Rattus norvegicus | 1 | cell-free format | Scientific Literature | ||
| 6. | ALA2329512 | A | Fraction unbound in human plasma | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 7. | ALA2327052 | B | Inhibition of human Nav1.5 expressed in HEK293 cells at >10 uM | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA2327053 | B | Inhibition of human Kv1.5 expressed in CHO cells assessed as decrease in channel current at > 10 uM by patch clamp analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA2327054 | B | Inhibition of human Cav1.2 expressed in HEK293 cells assessed as decrease in calcium immobilization at >10 uM by FLIPR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA2327055 | B | Agonist activity at rat TRPV4 | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
| 11. | ALA2327056 | B | Agonist activity at human TRPV4 | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA2327057 | B | Antagonist activity at rat TRPV4 | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
| 13. | ALA2327059 | A | Oral bioavailability in Sprague-Dawley rat at 2 mg/kg by HPLC-MS/MS analysis | Rattus norvegicus | 7 | organism-based format | Scientific Literature | ||
| 14. | ALA2327060 | A | Half life in Sprague-Dawley rat plasma at 2 mg/kg, po by HPLC-MS/MS analysis | Rattus norvegicus | 8 | organism-based format | Scientific Literature | ||
| 15. | ALA2327221 | A | Clearance in Sprague-Dawley rat plasma at 1 mg/kg, iv by HPLC-MS/MS analysis | Rattus norvegicus | 7 | organism-based format | Scientific Literature | ||
| 16. | ALA2327222 | B | Antagonist activity at human recombinant TRPV4 expressed in BacMam virus infected HEK MSRII cells assessed as inhibition of GSK1016790A-induced calcium immobilization treated 10 mins prior to TRPV4 agonist, GSK1016790A by FLIPR assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 17. | ALA4322960 | B | Antagonist activity at human TRPV4 | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 18. | ALA4628171 | B | Antagonist activity at TRPV4 (unknown origin) | Homo sapiens | 5 | single protein format | Scientific Literature |
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