# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3384913 | ADME | Half-life in human liver microsome S9 fraction at 1 uM up to 60 mins by LC-MS/MS analysis | Homo sapiens | 16 | ALA3351241 | microsome format | Scientific Literature | |
2. | ALA2328128 | Binding | Inhibition of 17beta-HSD2 in common marmoset placental microsomal fraction assessed as inhibition of [3H]E2 conversion to E1 at 1 uM by scintillation counting analysis | Callithrix jacchus | 5 | ALA2321834 | microsome format | Scientific Literature | |
3. | ALA2328129 | Binding | Inhibition of 17beta-HSD2 in mouse liver microsomal fraction assessed as inhibition of [3H]E2 conversion to E1 at 1 uM by scintillation counting analysis | Mus musculus | 5 | ALA2321834 | microsome format | Scientific Literature | |
4. | ALA2328130 | Binding | Inhibition of 17beta-HSD2 in rat liver microsomal fraction assessed as inhibition of [3H]E2 conversion to E1 at 1 uM by scintillation counting analysis | Rattus norvegicus | 5 | ALA2321834 | microsome format | Scientific Literature | |
5. | ALA2328131 | ADME | Cytotoxicity against human MDA-MB-231 cells at 50 uM after 3 hrs by MTT assay | Homo sapiens | 5 | ALA2321834 | cell-based format | Scientific Literature | |
6. | ALA2328133 | Binding | Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cell using [1,2,6,7-3H]cortisol as substrate at 2 uM after 10 mins by scintillation counting analysis | Homo sapiens | 9 | ALA2321834 | cell-based format | Scientific Literature | |
7. | ALA2328430 | Binding | Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cell using [1,2-3H]Cortisone as substrate at 2 uM after 10 mins by scintillation counting analysis | Homo sapiens | 9 | ALA2321834 | cell-based format | Scientific Literature | |
8. | ALA2328431 | Binding | Inhibition of human recombinant 17beta-HSD5 expressed in Escherichia coli using [1,2,6,7-3H]A-dione as substrate at 1 uM by scintillation counting analysis | Homo sapiens | 9 | ALA2321834 | assay format | Scientific Literature | |
9. | ALA2328432 | Binding | Inhibition of human recombinant 17beta-HSD4 SDR domain expressed in Escherichia coli using [6,7-3H]E2 as substrate at 1 uM by scintillation counting analysis | Homo sapiens | 9 | ALA2321834 | assay format | Scientific Literature | |
10. | ALA2328434 | Binding | Inhibition of 17beta-HSD2 in human MDA-MB-231 cells using [3H]E2 as substrate after 6 hrs by HPLC analysis | Homo sapiens | 14 | ALA2321834 | cell-based format | Scientific Literature | |
11. | ALA2328435 | Binding | Selectivity ratio of IC50 for 17beta-HSD1 in human placental microsomal fraction to IC50 for 17beta-HSD2 in human placental microsomal fraction | Homo sapiens | 19 | ALA2321834 | microsome format | Scientific Literature | |
12. | ALA2328436 | Binding | Inhibition of 17beta-HSD1 in human placental cytosolic fraction using [3H]E1 as substrate assessed as formation of E2 by HPLC analysis | Homo sapiens | 19 | ALA2321834 | assay format | Scientific Literature | |
13. | ALA2328437 | Binding | Inhibition of 17beta-HSD2 in human placental microsomal fraction using [3H]E2 as substrate assessed as formation of E1 by HPLC analysis | Homo sapiens | 19 | ALA2321834 | microsome format | Scientific Literature | |
14. | ALA2328438 | Binding | Displacement of [3H]E2 from human recombinant ERbeta after 1 hr by scintillation counting analysis relative to E2 | Homo sapiens | 19 | ALA2321834 | single protein format | Scientific Literature | |
15. | ALA2328439 | Binding | Displacement of [3H]E2 from human recombinant ERalpha after 1 hr by scintillation counting analysis relative to E2 | Homo sapiens | 19 | ALA2321834 | single protein format | Scientific Literature | |
16. | ALA2328440 | Binding | Inhibition of 17beta-HSD1 in human placental cytosolic fraction using [3H]E1 as substrate after 10 mins at 1 uM by HPLC analysis | Homo sapiens | 64 | ALA2321834 | assay format | Scientific Literature | |
17. | ALA2328441 | Binding | Inhibition of 17beta-HSD2 in human placental microsomal fraction using [3H]E2 as substrate at 1 uM after 20 mins by HPLC analysis | Homo sapiens | 64 | ALA2321834 | microsome format | Scientific Literature |