| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3384912 | ADME | Half-life in human liver microsome S9 fraction at 3 uM up to 45 mins by LC-MS/MS analysis | Homo sapiens | 6 | ALA3351241 | microsome format | Scientific Literature | |
| 2. | ALA3384913 | ADME | Half-life in human liver microsome S9 fraction at 1 uM up to 60 mins by LC-MS/MS analysis | Homo sapiens | 16 | ALA3351241 | microsome format | Scientific Literature | |
| 3. | ALA3384914 | Binding | Displacement of [3H]E2 from human placental microsomal 17beta-HSD2 after 20 mins by cell-free assay | Homo sapiens | 17 | ALA3351241 | assay format | Scientific Literature | |
| 4. | ALA3384915 | Binding | Displacement of [3H]E1 from human placental cytosolic17beta-HSD1 after 10 mins by cell-free assay | Homo sapiens | 17 | ALA3351241 | assay format | Scientific Literature | |
| 5. | ALA3384918 | Binding | Selectivity factor, ratio of IC50 for human placental cytosolic17beta-HSD1 to IC50 for human placental cytosolic17beta-HSD2 | Homo sapiens | 33 | ALA3351241 | assay format | Scientific Literature | |
| 6. | ALA3384921 | ADME | Drug metabolism in human liver microsome S9 fraction assessed as demethylation/hydroxylation metabolite formation by LC-MS/MS analysis | Homo sapiens | 3 | ALA3351241 | microsome format | Scientific Literature | |
| 7. | ALA3384922 | ADME | Drug metabolism in human liver microsome S9 fraction assessed as hydroxylation/N,S oxidation/epoxidation metabolite formation by LC-MS/MS analysis | Homo sapiens | 3 | ALA3351241 | microsome format | Scientific Literature | |
| 8. | ALA3384923 | ADME | Drug metabolism in human liver microsome S9 fraction assessed as acid metabolite formation by LC-MS/MS analysis | Homo sapiens | 3 | ALA3351241 | microsome format | Scientific Literature | |
| 9. | ALA3384924 | ADME | Drug metabolism in human liver microsome S9 fraction assessed as di-hydroxylation metabolite formation by LC-MS/MS analysis | Homo sapiens | 3 | ALA3351241 | microsome format | Scientific Literature | |
| 10. | ALA3384925 | ADME | Drug metabolism in human liver microsome S9 fraction assessed as demethylation metabolite formation by LC-MS/MS analysis | Homo sapiens | 3 | ALA3351241 | microsome format | Scientific Literature | |
| 11. | ALA3384926 | ADME | Drug metabolism in human liver microsome S9 fraction assessed as didemethylation metabolite formation by LC-MS/MS analysis | Homo sapiens | 3 | ALA3351241 | microsome format | Scientific Literature | |
| 12. | ALA2328128 | Binding | Inhibition of 17beta-HSD2 in common marmoset placental microsomal fraction assessed as inhibition of [3H]E2 conversion to E1 at 1 uM by scintillation counting analysis | Callithrix jacchus | 5 | ALA2321834 | microsome format | Scientific Literature | |
| 13. | ALA2328129 | Binding | Inhibition of 17beta-HSD2 in mouse liver microsomal fraction assessed as inhibition of [3H]E2 conversion to E1 at 1 uM by scintillation counting analysis | Mus musculus | 5 | ALA2321834 | microsome format | Scientific Literature | |
| 14. | ALA2328130 | Binding | Inhibition of 17beta-HSD2 in rat liver microsomal fraction assessed as inhibition of [3H]E2 conversion to E1 at 1 uM by scintillation counting analysis | Rattus norvegicus | 5 | ALA2321834 | microsome format | Scientific Literature | |
| 15. | ALA2328131 | ADME | Cytotoxicity against human MDA-MB-231 cells at 50 uM after 3 hrs by MTT assay | Homo sapiens | 5 | ALA2321834 | cell-based format | Scientific Literature | |
| 16. | ALA2328133 | Binding | Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cell using [1,2,6,7-3H]cortisol as substrate at 2 uM after 10 mins by scintillation counting analysis | Homo sapiens | 9 | ALA2321834 | cell-based format | Scientific Literature | |
| 17. | ALA2328430 | Binding | Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cell using [1,2-3H]Cortisone as substrate at 2 uM after 10 mins by scintillation counting analysis | Homo sapiens | 9 | ALA2321834 | cell-based format | Scientific Literature | |
| 18. | ALA2328431 | Binding | Inhibition of human recombinant 17beta-HSD5 expressed in Escherichia coli using [1,2,6,7-3H]A-dione as substrate at 1 uM by scintillation counting analysis | Homo sapiens | 9 | ALA2321834 | assay format | Scientific Literature | |
| 19. | ALA2328432 | Binding | Inhibition of human recombinant 17beta-HSD4 SDR domain expressed in Escherichia coli using [6,7-3H]E2 as substrate at 1 uM by scintillation counting analysis | Homo sapiens | 9 | ALA2321834 | assay format | Scientific Literature | |
| 20. | ALA2328434 | Binding | Inhibition of 17beta-HSD2 in human MDA-MB-231 cells using [3H]E2 as substrate after 6 hrs by HPLC analysis | Homo sapiens | 14 | ALA2321834 | cell-based format | Scientific Literature |
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