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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA2328568 B Inhibition of NaV1.7 ion channel (unknown origin) Homo sapiens 1,017 ALA2321810 single protein format Scientific Literature 2. ALA3301363 P ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5 4,197 ALA3301361 small-molecule physicochemical format AstraZeneca Deposited Data 3. ALA3301366 A ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with whole rat plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound. Rattus norvegicus 717 ALA3301361 cell-free format AstraZeneca Deposited Data 4. ALA4040119 A Volume of distribution at steady state in rat at 1 mg/kg, iv Rattus norvegicus 6 ALA4038312 organism-based format Scientific Literature 5. ALA4040120 A Plasma clearance in rat at 1 mg/kg, iv Rattus norvegicus 6 ALA4038312 organism-based format Scientific Literature 6. ALA4040121 A Plasma clearance in dog at 0.1 mg/kg, iv Canis lupus familiaris 6 ALA4038312 organism-based format Scientific Literature 7. ALA4040124 A Inhibition of human NaV1.5 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp method Homo sapiens 26 ALA4038312 cell-based format Scientific Literature 8. ALA4040125 B Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp method Homo sapiens 27 ALA4038312 cell-based format Scientific Literature 9. ALA4040126 A Inhibition of human NaV1.1 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp method Homo sapiens 5 ALA4038312 cell-based format Scientific Literature 10. ALA4040127 A Inhibition of human NaV1.2 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp method Homo sapiens 5 ALA4038312 cell-based format Scientific Literature 11. ALA4040128 B Inhibition of human NaV1.3 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp method Homo sapiens 5 ALA4038312 cell-based format Scientific Literature 12. ALA4040129 A Inhibition of human NaV1.6 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp method Homo sapiens 5 ALA4038312 cell-based format Scientific Literature 13. ALA4040130 B Inhibition of human NaV1.8 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp method Homo sapiens 5 ALA4038312 cell-based format Scientific Literature 14. ALA4040131 B Inhibition of rat NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp method Rattus norvegicus 5 ALA4038312 cell-based format Scientific Literature 15. ALA4040132 A Inhibition of CYP3A4 (unknown origin) Homo sapiens 26 ALA4038312 single protein format Scientific Literature 16. ALA4040133 A Inhibition of CYP2C9 (unknown origin) Homo sapiens 27 ALA4038312 single protein format Scientific Literature 17. ALA4040134 A Apparent intrinsic clearance in human liver microsomes Homo sapiens 26 ALA4038312 assay format Scientific Literature 18. ALA4040135 P Octanol-water distribution coefficient, log D of the compound at pH 7.4 by shake flask method 17 ALA4038312 small-molecule physicochemical format Scientific Literature 19. ALA4040136 P Solubility of the compound at pH 6.5 6 ALA4038312 small-molecule physicochemical format Scientific Literature 20. ALA4040137 A Intrinsic clearance in rat liver microsomes Rattus norvegicus 6 ALA4038312 assay format Scientific Literature