| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2327388 | B | Inhibition of MT-stimulated human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain ATPase activity expressed in Escherichia coli BL21 (DE3) by pyruvate kinase/lactate dehydrogenase-coupled assay | Homo sapiens | 15 | assay format | Scientific Literature | ||
| 2. | ALA2327389 | A | Metabolic stability in mouse liver microsomes at 3 uM after 0.5 to 45 mins by LC-MS/MS analysis | Mus musculus | 4 | microsome format | Scientific Literature | ||
| 3. | ALA2327390 | A | Metabolic stability in human liver microsomes at 3 uM after 0.5 to 45 mins by LC-MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 4. | ALA2327393 | F | Antitumor activity against human LXFS 538 cells xenografted in NMRI nu/nu mouse assessed as tumor regression at 15 mg/kg, ip measured within 17 days | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA2327406 | A | Inhibition of CYP2D6 (unknown origin) by LC-MS/MS analysis | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 6. | ALA2327407 | A | Inhibition of CYP3A4 (unknown origin) by LC-MS/MS analysis | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 7. | ALA2327408 | A | Inhibition of CYP2C9 (unknown origin) by LC-MS/MS analysis | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 8. | ALA2327409 | A | Inhibition of CYP2C19 (unknown origin) by LC-MS/MS analysis | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 9. | ALA2327410 | B | Inhibition of human ERG channel expressed in CHO cells by Ionworks HT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 10. | ALA2327411 | A | Inhibition of CYP1A2 (unknown origin) by LC-MS/MS analysis | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 11. | ALA2327412 | A | Fraction unbound in 100% human plasma at 5 uM by equilibrium dialysis method | Homo sapiens | 6 | cell-free format | Scientific Literature | ||
| 12. | ALA2327413 | A | Drug recovery in 100% human plasma at 5 uM by LC-MS/MS analysis | Homo sapiens | 6 | cell-free format | Scientific Literature | ||
| 13. | ALA2327415 | A | Intrinsic clearance in human hepatocytes assessed per 10'6 cells at 3 uM after 1 to 60 mins by LC-MS/MS analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 14. | ALA2327416 | A | Half life in human hepatocytes at 3 uM by LC-MS/MS analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 15. | ALA2327419 | P | Distribution coefficient, log D of the compound in n-octanol buffer at pH 7.4 by shake flask method | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 16. | ALA2327042 | P | Solubility of the compound in phosphate buffered saline at pH 7.4 after 2 hrs by turbidimetric analysis | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 17. | ALA2327043 | P | Partition coefficient, log P of the compound by potentiometric method | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 18. | ALA2327045 | P | Solubility of the compound in phosphate buffered saline at pH 2.0 after 2 hrs by turbidimetric analysis | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 19. | ALA2327046 | P | Solubility of the compound in phosphate buffered saline at pH 6.0 after 2 hrs by turbidimetric analysis | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 20. | ALA2327047 | F | Growth inhibition of human BxPC3 cells after 72 hrs by Alamar blue assay | Homo sapiens | 15 | cell-based format | Scientific Literature |
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