# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2329986 | F | Cytotoxicity against human NCI-H1417 cells assessed as growth inhibition after 4 days by WST assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
2. | ALA2329987 | F | Cytotoxicity against human NCI-H187 cells assessed as growth inhibition after 4 days by WST assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
3. | ALA2329988 | F | Antitumor activity against human NCI-H146 cells xenografted in SCID mouse assessed as tumor regression at 15 mg/kg, iv administered 5 days per week for 2 weeks | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
4. | ALA2329991 | T | Toxicity in SCID mouse 15 mg/kg, iv administered 5 days per week for 2 weeks | Mus musculus | 2 | organism-based format | Scientific Literature | ||
5. | ALA2329994 | T | Toxicity in iv dosed SCID mouse assessed as weight loss administered 5 days per week for 2 weeks | Mus musculus | 2 | organism-based format | Scientific Literature | ||
6. | ALA2329995 | T | Toxicity in SCID mouse assessed as weight loss at 25 mg/kg, iv administered 5 days per week for 2 weeks relative to control | Mus musculus | 2 | organism-based format | Scientific Literature | ||
7. | ALA2329996 | T | Toxicity in SCID mouse assessed as weight loss at 15 mg/kg, iv administered 5 days per week for 2 weeks relative to control | Mus musculus | 2 | organism-based format | Scientific Literature | ||
8. | ALA2329997 | B | Binding affinity to MCL1 (unknown origin) after 2 hrs by fluorescence polarization assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
9. | ALA2329998 | F | Cytotoxicity against human NCI-H146 cells assessed as growth inhibition after 4 days by WST assay | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
10. | ALA2329999 | B | Binding affinity to BCL-XL (unknown origin) after 2 hrs by fluorescence polarization assay | Homo sapiens | 28 | single protein format | Scientific Literature | ||
11. | ALA2330000 | B | Binding affinity to BCL2 (unknown origin) after 2 hrs by fluorescence polarization assay | Homo sapiens | 28 | single protein format | Scientific Literature | ||
12. | ALA2330001 | F | Induction of apoptosis in human NCI-H146 cells xenografted in SCID mouse assessed as increase in PARP cleavage at 15 mg/kg, iv after 3 to 6 hrs by Western blotting analysis | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
13. | ALA2330002 | F | Induction of apoptosis in human NCI-H146 cells xenografted in SCID mouse assessed as increase in caspase-3 cleavage at 15 mg/kg, iv after 3 to 6 hrs by Western blotting analysis | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
14. | ALA2330003 | F | Cytotoxicity against human NCI-H1963 cells assessed as growth inhibition after 4 days by WST assay | Homo sapiens | 4 | cell-based format | Scientific Literature |