Inhibition of LPS-induced TNF-alpha secretion in mouse RAW264.7 cells at 10 uM pretreated for 2 hrs prior to LPS addition measured after 22 hrs by ELISA
Inhibition of LPS-induced IL6 production in mouse RAW264.7 cells at 10 uM preincubated for 30 mins prior to LPS challenge measured after 24 hrs by ELISA
Inhibition of LPS-induced TNF-alpha production in mouse RAW264.7 cells at 10 uM preincubated for 30 mins prior to LPS challenge measured after 24 hrs by ELISA
Antiinflammatory activity in LPS-induced C57BL/6 mouse sepsis model assessed as inhibition of neutrophils infiltration in lung by measuring MPO activity at 10 mg/kg, iv administered 15 mins prior to LPS challenge measured after 6 hrs in presence of O-dianisidine dihydrochloride relative to control
Antiinflammatory activity in LPS-induced C57BL/6 mouse sepsis model assessed as reduction in airspace inflammation in lung at 10 mg/kg, iv administered 15 mins prior to LPS challenge measured after 6 hrs by hematoxylin and eosin staining
Antiinflammatory activity in LPS-induced C57BL/6 mouse sepsis model assessed as decrease in pulmonary lobule structural changes at 10 mg/kg, iv administered 15 mins prior to LPS challenge measured after 6 hrs by hematoxylin and eosin staining
Antiinflammatory activity in LPS-induced C57BL/6 mouse sepsis model assessed as inhibition of macrophage infiltration in lung at 10 mg/kg, iv administered 15 mins prior to LPS challenge measured after 6 hrs by F4/80 and hematoxylin-staining based microscopy
Downregulation of TNF-alpha mRNA level in lung of LPS-induced C57BL/6 mouse sepsis model at 10 mg/kg, iv administered 15 mins prior to LPS challenge measured after 6 hrs by RT-qPCR analysis
Downregulation of IL-6 mRNA level in lung of LPS-induced C57BL/6 mouse sepsis model at 10 mg/kg, iv administered 15 mins prior to LPS challenge measured after 6 hrs by RT-qPCR analysis
Downregulation of IL-12 mRNA level in lung of LPS-induced C57BL/6 mouse sepsis model at 10 mg/kg, iv administered 15 mins prior to LPS challenge measured after 6 hrs by RT-qPCR analysis
Downregulation of IL-33 mRNA level in lung of LPS-induced C57BL/6 mouse sepsis model at 10 mg/kg, iv administered 15 mins prior to LPS challenge measured after 6 hrs by RT-qPCR analysis
Downregulation of IL-1beta mRNA level in lung of LPS-induced C57BL/6 mouse sepsis model at 10 mg/kg, iv administered 15 mins prior to LPS challenge measured after 6 hrs by RT-qPCR analysis
Downregulation of COX2 mRNA level in lung of LPS-induced C57BL/6 mouse sepsis model at 10 mg/kg, iv administered 15 mins prior to LPS challenge measured after 6 hrs by RT-qPCR analysis