| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2329579 | F | Cell cycle arrest in human SKOV3 cells assessed as accumulation in G2/M phase at 100 nM after 24 hrs by FACS analysis (Rvb = 21.8%) | Homo sapiens | 4 | ALA2321780 | cell-based format | Scientific Literature | |
| 2. | ALA2327522 | F | Cell cycle arrest in human SKOV3 cells assessed as accumulation in S phase at 100 nM after 24 hrs by FACS analysis (Rvb = 18.4%) | Homo sapiens | 4 | ALA2321780 | cell-based format | Scientific Literature | |
| 3. | ALA2327523 | F | Cell cycle arrest in human SKOV3 cells assessed as accumulation in G0/G1 phase at 100 nM after 24 hrs by FACS analysis (Rvb = 51.1%) | Homo sapiens | 4 | ALA2321780 | cell-based format | Scientific Literature | |
| 4. | ALA2327524 | F | Cell cycle arrest in human MCF7 cells assessed as accumulation in G2/M phase at 100 nM after 24 hrs by FACS analysis (Rvb = 22.4%) | Homo sapiens | 4 | ALA2321780 | cell-based format | Scientific Literature | |
| 5. | ALA2327525 | F | Cell cycle arrest in human MCF7 cells assessed as accumulation in G0/G1 phase at 100 nM after 24 hrs by FACS analysis (Rvb = 48.2%) | Homo sapiens | 4 | ALA2321780 | cell-based format | Scientific Literature | |
| 6. | ALA2327526 | F | Cell cycle arrest in human MCF7 cells assessed as accumulation in S phase at 100 nM after 24 hrs by FACS analysis (Rvb = 19.6%) | Homo sapiens | 4 | ALA2321780 | cell-based format | Scientific Literature | |
| 7. | ALA2327527 | F | Cell cycle arrest in human PC3 cells assessed as accumulation in G2/M phase at 100 nM after 24 hrs by FACS analysis (Rvb = 26.3%) | Homo sapiens | 4 | ALA2321780 | cell-based format | Scientific Literature | |
| 8. | ALA2327528 | F | Cell cycle arrest in human PC3 cells assessed as accumulation in S phase at 100 nM after 24 hrs by FACS analysis (Rvb = 14.2%) | Homo sapiens | 4 | ALA2321780 | cell-based format | Scientific Literature | |
| 9. | ALA2327529 | F | Cell cycle arrest in human PC3 cells assessed as accumulation in G0/G1 phase at 100 nM after 24 hrs by FACS analysis (Rvb = 32.6%) | Homo sapiens | 4 | ALA2321780 | cell-based format | Scientific Literature | |
| 10. | ALA2327530 | F | Cell cycle arrest in human DU145 cells assessed as accumulation in S phase at 100 nM after 24 hrs by FACS analysis (Rvb = 4.5%) | Homo sapiens | 4 | ALA2321780 | cell-based format | Scientific Literature | |
| 11. | ALA2327531 | F | Cell cycle arrest in human DU145 cells assessed as accumulation in G2/M phase at 100 nM after 24 hrs by FACS analysis (Rvb = 31%) | Homo sapiens | 4 | ALA2321780 | cell-based format | Scientific Literature | |
| 12. | ALA2327532 | F | Cell cycle arrest in human DU145 cells assessed as accumulation in G0/G1 phase at 100 nM after 24 hrs by FACS analysis (Rvb = 53.2%) | Homo sapiens | 4 | ALA2321780 | cell-based format | Scientific Literature | |
| 13. | ALA2327543 | B | Inhibition of KIFC3 (unknown origin)-mediated ATP hydrolysis assessed as residual activity at 1 uM after 10 to 20 mins by spectrophotometric analysis | Homo sapiens | 8 | ALA2321780 | single protein format | Scientific Literature | |
| 14. | ALA2327675 | B | Inhibition of KNH (unknown origin)-mediated ATP hydrolysis assessed as residual activity at 1 uM after 10 to 20 mins by spectrophotometric analysis | Homo sapiens | 8 | ALA2321780 | single protein format | Scientific Literature | |
| 15. | ALA2327676 | B | Inhibition of MCAK (unknown origin)-mediated ATP hydrolysis assessed as residual activity at 1 uM after 10 to 20 mins by spectrophotometric analysis | Homo sapiens | 8 | ALA2321780 | single protein format | Scientific Literature | |
| 16. | ALA2327677 | B | Inhibition of CENP-E (unknown origin)-mediated ATP hydrolysis assessed as residual activity at 1 uM after 10 to 20 mins by spectrophotometric analysis | Homo sapiens | 8 | ALA2321780 | single protein format | Scientific Literature | |
| 17. | ALA2327678 | B | Inhibition of KSP (unknown origin)-mediated ATP hydrolysis assessed as residual activity at 1 uM after 10 to 20 mins by spectrophotometric analysis | Homo sapiens | 8 | ALA2321780 | single protein format | Scientific Literature | |
| 18. | ALA3301363 | P | ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5 | 4,197 | ALA3301361 | small-molecule physicochemical format | AstraZeneca Deposited Data | ||
| 19. | ALA3301365 | A | ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with whole human plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound. | Homo sapiens | 1,614 | ALA3301361 | cell-free format | AstraZeneca Deposited Data | |
| 20. | ALA5167462 | B | Inhibition of kinesin spindle protein (unknown origin) | Homo sapiens | 1 | ALA5154920 | assay format | Scientific Literature |
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