| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3768905 | Binding | Inhibition of full length human recombinant PDE4B1 using [3H]-cAMP as substrate by scintillation proximity assay | Homo sapiens | 7 | ALA3763060 | single protein format | Scientific Literature | |
| 2. | ALA3768906 | Binding | Inhibition of full length human recombinant PDE10A using [3H]-cAMP as substrate by scintillation proximity assay | Homo sapiens | 1 | ALA3763060 | single protein format | Scientific Literature | |
| 3. | ALA3768907 | Binding | Inhibition of full length human recombinant PDE2A3 using [3H]-cAMP as substrate by scintillation proximity assay | Homo sapiens | 1 | ALA3763060 | single protein format | Scientific Literature | |
| 4. | ALA3768908 | Binding | Inhibition of full length human recombinant PDE11A4 using [3H]-cAMP as substrate by scintillation proximity assay | Homo sapiens | 1 | ALA3763060 | single protein format | Scientific Literature | |
| 5. | ALA3768909 | Functional | Antitrypanosomal activity against Trypanosoma brucei assessed as inhibition of parasite growth after 48 hrs by resazurin assay | Trypanosoma brucei | 1 | ALA3763060 | organism-based format | Scientific Literature | |
| 6. | ALA3768910 | Functional | Antitrypanosomal activity against suramin-sensitive Trypanosoma brucei brucei Squib427 assessed as inhibition of parasite growth | Trypanosoma brucei brucei | 15 | ALA3763060 | organism-based format | Scientific Literature | |
| 7. | ALA3768911 | ADME | Cytotoxicity against human MRC5 cells assessed as growth inhibition | Homo sapiens | 15 | ALA3763060 | cell-based format | Scientific Literature | |
| 8. | ALA3769077 | Toxicity | Selectivity index, ratio of CC50 for human MRC5 cells to EC50 for suramin-sensitive Trypanosoma brucei brucei Squib427 | 13 | ALA3763060 | cell-based format | Scientific Literature | ||
| 9. | ALA3769078 | Binding | Inhibition of full length human recombinant PDE3A1 using [3H]-cAMP as substrate by scintillation proximity assay | Homo sapiens | 1 | ALA3763060 | assay format | Scientific Literature | |
| 10. | ALA3769079 | Binding | Inhibition of full length human recombinant PDE1B1 using [3H]-cAMP as substrate by scintillation proximity assay | Homo sapiens | 1 | ALA3763060 | single protein format | Scientific Literature | |
| 11. | ALA3769080 | Binding | Inhibition of full length human recombinant PDE4B2 using [3H]-cAMP as substrate by scintillation proximity assay | Homo sapiens | 1 | ALA3763060 | single protein format | Scientific Literature | |
| 12. | ALA3769081 | Binding | Inhibition of full length human recombinant PDE4D3 using [3H]-cAMP as substrate by scintillation proximity assay | Homo sapiens | 1 | ALA3763060 | single protein format | Scientific Literature | |
| 13. | ALA3769082 | Binding | Inhibition of full length human recombinant PDE5A1 using [3H]-cGMP as substrate by scintillation proximity assay | Homo sapiens | 1 | ALA3763060 | single protein format | Scientific Literature | |
| 14. | ALA3769083 | Binding | Inhibition of full length human recombinant PDE7A1 using [3H]-cAMP as substrate by scintillation proximity assay | Homo sapiens | 1 | ALA3763060 | single protein format | Scientific Literature | |
| 15. | ALA3769084 | Binding | Inhibition of full length human recombinant PDE8B using [3H]-cAMP as substrate by scintillation proximity assay | Homo sapiens | 1 | ALA3763060 | single protein format | Scientific Literature | |
| 16. | ALA3769085 | Binding | Inhibition of Trypanosoma brucei PDEB2 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Trypanosoma brucei | 1 | ALA3763060 | assay format | Scientific Literature | |
| 17. | ALA3769086 | Binding | Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Trypanosoma brucei | 23 | ALA3763060 | single protein format | Scientific Literature | |
| 18. | ALA3769087 | Binding | Inhibition of full length human recombinant PDE9A3 using [3H]-cAMP as substrate by scintillation proximity assay | Homo sapiens | 1 | ALA3763060 | single protein format | Scientific Literature | |
| 19. | ALA3769088 | Binding | Selectivity ratio of IC50 for Trypanosoma brucei recombinant PDEB1 to IC50 for full length human recombinant PDE4B1 | 7 | ALA3763060 | assay format | Scientific Literature | ||
| 20. | ALA3769089 | Physicochemical | Solubility of compound in 0.05 M phosphate buffer at pH 7.4 | 3 | ALA3763060 | small-molecule physicochemical format | Scientific Literature |
The page will load shortly, Thanks for your patience!