# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2344627 | B | Inhibition of human Cyp11B2 transfected in chinese hamster V79MZ cells using deoxycorticosterone as substrate incubated for 60 mins prior to substrate addition measured after 50 mins by HPLC analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
2. | ALA2345044 | B | Inhibition of human Cyp11B1 transfected in chinese hamster V79MZ cells using deoxycorticosterone as substrate incubated for 60 mins prior to substrate addition measured after 25 mins by HPLC analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
3. | ALA3624350 | B | Inhibition of human CYP11B2 expressed in V79 cells assessed as aldosterone level after 3 hrs by HTRF assay in presence of 125 nM 11-deoxycorticosterone | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
4. | ALA3624351 | B | Inhibition of human CYP11B1 expressed in V79 cells assessed as cortisol level after 3 hrs by HTRF assay in presence of 250 nM 11-deoxycortisol | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
5. | ALA3625233 | A | Intrinsic clearance in Sprague-Dawley rat liver microsomes by LC/MS method | Rattus norvegicus | 6 | assay format | Scientific Literature | ||
6. | ALA3625347 | A | Oral bioavailability in Sprague-Dawley rat at 2 mg/kg administered through gavage | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
7. | ALA3625348 | A | Dose normalized AUC in Sprague-Dawley rat at 2 mg/kg, po administered through gavage | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
8. | ALA3625349 | A | Plasma clearance in Sprague-Dawley rat at 2 mg/kg, po administered through gavage by LC/MS/MS method | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
9. | ALA3625350 | A | Half life in Sprague-Dawley rat at 2 mg/kg, po administered through gavage by LC/MS/MS method | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
10. | ALA3625351 | B | Inhibition of human CYP17 expressed in COS7 cells assessed as DHEA level after 3 hrs by EIA assay in presence of 360 nM 17-hydroxypregnenolone | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
11. | ALA3625352 | B | Inhibition of human CYP19 | Homo sapiens | 4 | single protein format | Scientific Literature | ||
12. | ALA3625353 | A | Inhibition of human CYP3A4 | Homo sapiens | 4 | single protein format | Scientific Literature | ||
13. | ALA3625364 | B | Inhibition of rhesus monkey CYP11B2 expressed in V79 cells assessed as aldosterone level after 3 hrs by HTRF assay in presence of 125 nM 11-deoxycorticosterone | Macaca mulatta | 3 | cell-based format | Scientific Literature | ||
14. | ALA3625365 | B | Inhibition of rat CYP11B2 expressed in V79 cells assessed as aldosterone level after 3 hrs by HTRF assay in presence of 500 nM 11-deoxycorticosterone | Rattus norvegicus | 3 | cell-based format | Scientific Literature |