Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay relative to 5HT
Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay relative to 5HT
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release by fluorescence assay relative to 5HT
Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release by fluorescence assay relative to 5HT
Procognitive effect in C57BI/6J mouse assessed as time spent in familiar arm at 0.43 mg/kg, po administered 30 mins prior to acquisition trial measured after 24 hrs in presence of SB242084
Procognitive effect in C57Bl/6J mouse assessed as time spent in novel arm at 0.43 mg/kg, po administered 30 mins prior to acquisition trial measured after 24 hrs in presence of SB242084
Procognitive effect in C57Bl/6J mouse assessed as number of familiar arm entry at 0.43 mg/kg, po administered 30 mins prior to acquisition trial measured after 24 hrs in presence of SB242084
Procognitive effect in C57Bl/6J mouse assessed as number of novel arm entry at 0.43 mg/kg, po administered 30 mins prior to acquisition trial measured after 24 hrs in presence of SB242084
Procognitive effect in C57Bl/6J mouse assessed as distance traveled in the familiar arm at 0.43 mg/kg, po administered 30 mins prior to acquisition trial measured after 24 hrs in presence of SB242084 (Rvb = 31.5 +/- 2.9%)
Procognitive effect in C57Bl/6J mouse assessed as distance traveled in the novel arm at 0.43 mg/kg, po administered 30 mins prior to acquisition trial measured after 24 hrs in presence of SB242084 (Rvb = 37 +/-5.8%)
Procognitive effect in C57Bl/6J mouse assessed as time spent in familiar arm at 0.43 mg/kg, po administered 30 mins prior to acquisition trial measured after 24 hrs by Y-maze test
Procognitive effect in C57Bl/6J mouse assessed as number of familiar arm entry at 0.43 mg/kg, po administered 30 mins prior to acquisition trial measured after 24 hrs by Y-maze test
Procognitive effect in C57Bl/6J mouse assessed as time spent in novel arm at 0.43 mg/kg, po administered 30 mins prior to acquisition trial measured after 24 hrs by Y-maze test
Procognitive effect in C57Bl/6J mouse assessed as number of novel arm entries at 0.43 mg/kg, po administered 30 mins prior to acquisition trial measured after 24 hrs by Y-maze test
Procognitive effect in C57Bl/6J mouse assessed as distance traveled in the familiar arm at 0.43 mg/kg, po administered 30 mins prior to acquisition trial measured after 24 hrs by Y-maze test (Rvb =31.5 +/- 2.9%)
Procognitive effect in C57Bl/6J mouse assessed as distance traveled in the novel arm at 0.43 mg/kg, po administered 30 mins prior to acquisition trial measured after 24 hrs by Y-maze test (Rvb = 37 +/- 5.8%)