| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2341048 | A | Metabolic stability in heat inactivated human liver microsomes assessed as compound remaining at 10 uM measured at 60 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA2331169 | microsome format | Scientific Literature | |
| 2. | ALA2341049 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 10 uM measured at 60 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA2331169 | microsome format | Scientific Literature | |
| 3. | ALA2341050 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 10 uM measured at 30 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA2331169 | microsome format | Scientific Literature | |
| 4. | ALA2341051 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 10 uM measured at 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA2331169 | microsome format | Scientific Literature | |
| 5. | ALA2341052 | A | Metabolic stability in heat inactivated human liver microsomes assessed as compound remaining at 1 uM measured at 60 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA2331169 | microsome format | Scientific Literature | |
| 6. | ALA2341053 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM measured at 60 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA2331169 | microsome format | Scientific Literature | |
| 7. | ALA2341054 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM measured at 30 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA2331169 | microsome format | Scientific Literature | |
| 8. | ALA2346466 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM measured at 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA2331169 | microsome format | Scientific Literature | |
| 9. | ALA4042549 | B | Binding affinity to human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated for 3 mins followed by addition of GABA measured after 3 mins by FLIPR assay | Homo sapiens | 10 | ALA4041524 | cell-based format | Scientific Literature | |
| 10. | ALA4042550 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 4 uM measured after 30 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 10 | ALA4041524 | assay format | Scientific Literature | |
| 11. | ALA4042551 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining at 4 uM measured after 30 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 10 | ALA4041524 | assay format | Scientific Literature | |
| 12. | ALA4042552 | A | Metabolic stability in rat liver microsomes assessed as compound remaining at 4 uM measured after 30 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 10 | ALA4041524 | assay format | Scientific Literature | |
| 13. | ALA4042553 | A | Cytotoxicity against HEK293T cells assessed as viable cells measured after 18 hrs by CellTiter-Glo assay | Homo sapiens | 10 | ALA4041524 | cell-based format | Scientific Literature | |
| 14. | ALA4042554 | A | Binding affinity to human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated for 3 mins followed by addition of GABA measured after 3 mins by FLIPR assay | Homo sapiens | 10 | ALA4041524 | cell-based format | Scientific Literature | |
| 15. | ALA4042555 | A | Total plasma concentration in Sprague-Dawley rat at 10 mg/kg, po measured after 15 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4041524 | organism-based format | Scientific Literature | |
| 16. | ALA4042556 | A | Total plasma concentration in Sprague-Dawley rat at 10 mg/kg, po measured after 30 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4041524 | organism-based format | Scientific Literature | |
| 17. | ALA4042557 | A | Total plasma concentration in Sprague-Dawley rat at 10 mg/kg, po measured after 60 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4041524 | organism-based format | Scientific Literature | |
| 18. | ALA4042558 | A | Total plasma concentration in Sprague-Dawley rat at 10 mg/kg, po measured after 120 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4041524 | organism-based format | Scientific Literature | |
| 19. | ALA4042559 | A | Drug uptake in Sprague-Dawley rat brain at 10 mg/kg, po measured after 120 mins by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4041524 | organism-based format | Scientific Literature | |
| 20. | ALA4042561 | A | Drug metabolism in Sprague-Dawley rat brain assessed as (E)-8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylic acid formation at 10 mg/kg, po measured after 120 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4041524 | organism-based format | Scientific Literature |
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