# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2340567 | F | Sedative activity in rat assessed as reduction of D-amphetamine sulfate-induced locomotion at 10 to 100 mg/kg, ip administered 20 mins prior to testing measured for 90 mins relative to vehicle-treated control | Rattus norvegicus | 1 | ALA2331169 | organism-based format | Scientific Literature | |
2. | ALA2340569 | F | Anxiolytic activity in rat assessed as increase in time spent in lighted area at 10 to 100 mg/kg, ip administered 20 mins prior to testing measured for 30 mins by light/dark cycle test relative to vehicle-treated control | Rattus norvegicus | 1 | ALA2331169 | organism-based format | Scientific Literature | |
3. | ALA2340570 | B | Agonist activity at rat GABAA alpha5beta3gamma2 receptor expressed in Xenopus oocytes assessed as stimulation of GABA-induced chloride current at 1 uM incubated 30 secs prior to GABA induction measured after 15 mins by two-electrode voltage clamp assay relative to control | Rattus norvegicus | 6 | ALA2331169 | cell-based format | Scientific Literature | |
4. | ALA2340571 | B | Agonist activity at rat GABAA alpha5beta3gamma2 receptor expressed in Xenopus oocytes assessed as stimulation of GABA-induced chloride current at 100 nM incubated 30 secs prior to GABA induction measured after 15 mins by two-electrode voltage clamp assay relative to control | Rattus norvegicus | 6 | ALA2331169 | cell-based format | Scientific Literature | |
5. | ALA2340572 | B | Agonist activity at rat GABAA alpha3beta3gamma2 receptor expressed in Xenopus oocytes assessed as stimulation of GABA-induced chloride current at 1 uM incubated 30 secs prior to GABA induction measured after 15 mins by two-electrode voltage clamp assay relative to control | Rattus norvegicus | 6 | ALA2331169 | cell-based format | Scientific Literature | |
6. | ALA2340573 | B | Agonist activity at rat GABAA alpha3beta3gamma2 receptor expressed in Xenopus oocytes assessed as stimulation of GABA-induced chloride current at 100 nM incubated 30 secs prior to GABA induction measured after 15 mins by two-electrode voltage clamp assay relative to control | Rattus norvegicus | 6 | ALA2331169 | cell-based format | Scientific Literature | |
7. | ALA2340574 | B | Agonist activity at rat GABAA alpha2beta3gamma2 receptor expressed in Xenopus oocytes assessed as stimulation of GABA-induced chloride current at 1 uM incubated 30 secs prior to GABA induction measured after 15 mins by two-electrode voltage clamp assay relative to control | Rattus norvegicus | 6 | ALA2331169 | cell-based format | Scientific Literature | |
8. | ALA2341045 | B | Agonist activity at rat GABAA alpha2beta3gamma2 receptor expressed in Xenopus oocytes assessed as stimulation of GABA-induced chloride current at 100 nM incubated 30 secs prior to GABA induction measured after 15 mins by two-electrode voltage clamp assay relative to control | Rattus norvegicus | 6 | ALA2331169 | cell-based format | Scientific Literature | |
9. | ALA2341046 | B | Agonist activity at rat GABAA alpha1beta3gamma2 receptor expressed in Xenopus oocytes assessed as stimulation of GABA-induced chloride current at 1 uM incubated 30 secs prior to GABA induction measured after 15 mins by two-electrode voltage clamp assay relative to control | Rattus norvegicus | 6 | ALA2331169 | cell-based format | Scientific Literature | |
10. | ALA2341047 | B | Agonist activity at rat GABAA alpha1beta3gamma2 receptor expressed in Xenopus oocytes assessed as stimulation of GABA-induced chloride current at 100 nM incubated 30 secs prior to GABA induction measured after 15 mins by two-electrode voltage clamp assay relative to control | Rattus norvegicus | 6 | ALA2331169 | cell-based format | Scientific Literature | |
11. | ALA2341048 | A | Metabolic stability in heat inactivated human liver microsomes assessed as compound remaining at 10 uM measured at 60 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA2331169 | microsome format | Scientific Literature | |
12. | ALA2341049 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 10 uM measured at 60 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA2331169 | microsome format | Scientific Literature | |
13. | ALA2341050 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 10 uM measured at 30 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA2331169 | microsome format | Scientific Literature | |
14. | ALA2341051 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 10 uM measured at 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA2331169 | microsome format | Scientific Literature | |
15. | ALA2341052 | A | Metabolic stability in heat inactivated human liver microsomes assessed as compound remaining at 1 uM measured at 60 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA2331169 | microsome format | Scientific Literature | |
16. | ALA2341053 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM measured at 60 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA2331169 | microsome format | Scientific Literature | |
17. | ALA2341054 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM measured at 30 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA2331169 | microsome format | Scientific Literature | |
18. | ALA2346466 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM measured at 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA2331169 | microsome format | Scientific Literature |