Antidiabetic activity against high diet fed streptozotocin-challenged SKH2 mouse type 2 diabetes model assessed as reduction in visceral fat accumulation at 56 umol/kg, ip bid for 50 days measured on day 50 relative to control
Antidiabetic activity against high diet fed streptozotocin-challenged SKH2 mouse type 2 diabetes model assessed as increase in ratio HDL/LDL at 56 umol/kg, ip bid for 50 days measured on day 50 relative to control
Antioxidant activity against high diet fed streptozotocin-challenged SKH2 mouse type 2 diabetes model assessed as reduction in plasma malondialdehyde level at 56 umol/kg, ip bid for 50 days measured on day 50 relative to control
Antidiabetic activity against high diet fed streptozotocin-challenged SKH2 mouse type 2 diabetes model assessed as maintenance of initial triglyceride level at 56 umol/kg, ip bid for 50 days
Antidiabetic activity against high diet fed streptozotocin-challenged SKH2 mouse type 2 diabetes model assessed as maintenance of initial HDL level at 56 umol/kg, ip bid for 50 days
Antidiabetic activity against high diet fed streptozotocin-challenged SKH2 mouse type 2 diabetes model assessed as reduction in plasma LDL level at 56 umol/kg, ip bid for 50 days measured on day 50 relative to control
Antidiabetic activity against high diet fed streptozotocin-challenged SKH2 mouse type 2 diabetes model assessed as reduction in plasma LDL level at 56 umol/kg, ip bid for 50 days measured on day 43 relative to control
Antidiabetic activity against high diet fed streptozotocin-challenged SKH2 mouse type 2 diabetes model assessed as reduction in plasma total cholesterol level at 56 umol/kg, ip bid for 50 days measured on day 50 relative to control
Antidiabetic activity against high diet fed streptozotocin-challenged SKH2 mouse type 2 diabetes model assessed as reduction in plasma total cholesterol level at 56 umol/kg, ip bid for 50 days measured on day 43 relative to control
Toxicity in high diet fed streptozotocin-challenged SKH2 mouse assessed as increase in food intake at 56 umol/kg, ip bid for 50 days relative to control
Antidiabetic activity against high diet fed SKH2 mouse assessed as decrease in streptozotocin-induced rise in blood glucose level at 56 umol/kg, ip bid for 50 days
Antidiabetic activity against high diet fed streptozotocin-challenged SKH2 mouse type 2 diabetes model assessed as change in body weight at 56 umol/kg, ip bid for 50 days measured up to day 35
Antiinflammatory activity in SKH2 mouse assessed as reduction in carrageenan-induced paw edema at 0.3 mmol/kg, ip after carrageenan challenge measured after 3.5 hrs relative to control
Antidyslipidemic activity against triton WR1339-induced hyperlipidemia in rat assessed as reduction in plasma triglyceride level at 56 umol/kg, ip after 24 hrs (Rvb = 580%)
Antidyslipidemic activity against triton WR1339-induced hyperlipidemia in rat assessed as reduction in plasma total cholesterol level at 56 umol/kg, ip after 24 hrs (Rvb = 260%)
Inhibition of squalene synthase in rat liver microsomes assessed as inhibition of [3H] FPP conversion to squalene after 10 mins by scintillation counting analysis
Antioxidant activity against CuSO4-induced human LDL oxidation assessed as increase in lag time incubated for 5 mins prior to CuSO4 addition measured every 10 mins for 5 hrs by spectrophotometric analysis relative to control
Antioxidant activity against CuSO4-induced human LDL oxidation assessed as amount of dienes formed in decomposition phase at 1 uM incubated for 5 mins prior to CuSO4 addition measured every 10 mins for 5 hrs by spectrophotometric analysis (Rvb = 490.9 nmol/mg)