| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2344663 | F | Reversal of contextual fear memory deficit in APP/PS1 transgenic mouse assessed as increase in freezing behavior at 3 mg/kg/day, ip administered 3 weeks measured after 9 to 12 weeks by 2 day radial arm water maze test (Rvb = 10%) | Mus musculus | 1 | ALA2331505 | organism-based format | Scientific Literature | |
| 2. | ALA2344664 | F | Reversal of post synaptic dysfunction in APP/PS1 transgenic mouse assessed as increase in theta burst-induced long term potentiation at 3 mg/kg/day, ip administered 3 weeks measured after 9 to 12 weeks by 2 day radial arm water maze test (Rvb = 112.29 9.12%) | Mus musculus | 1 | ALA2331505 | organism-based format | Scientific Literature | |
| 3. | ALA2344665 | F | Reversal of contextual fear memory deficit in APP/PS1 transgenic mouse assessed as increase in freezing behavior at 3 mg/kg, ip after 3 weeks (Rvb = 10%) | Mus musculus | 1 | ALA2331505 | organism-based format | Scientific Literature | |
| 4. | ALA2345091 | F | Reversal of post synaptic dysfunction in APP/PS1 transgenic mouse hippocampal assessed as increase in theta burst-induced long term potentiation at 50 nM incubated 10 mins prior to theta burst induction measured after 2 hrs for 5 mins by electrophysiological assay (Rvb = 145.84 7.78%) | Mus musculus | 1 | ALA2331505 | tissue-based format | Scientific Literature | |
| 5. | ALA2345092 | F | Reversal of contextual fear memory deficit in amyloid beta42-infused mouse assessed as increase in freezing behavior at 3 to 10 mg/kg, po administered immediately post electric shock measured after 24 hrs (Rvb = 10%) | Mus musculus | 1 | ALA2331505 | organism-based format | Scientific Literature | |
| 6. | ALA2345093 | F | Reversal of amyloid beta42-induced post synaptic dysfunction in mouse hippocampal assessed as increase in theta burst-induced long term potentiation at 50 nM incubated 10 mins prior to theta burst induction measured after 60 mins for 5 mins by electrophysiological assay (Rvb = 144.65 9.99%) | Mus musculus | 1 | ALA2331505 | tissue-based format | Scientific Literature | |
| 7. | ALA2345094 | A | Ratio of AUC (0 to infinity) in mouse brain to AUC (0 to infinity) in mouse plasma | Mus musculus | 1 | ALA2331505 | cell-free format | Scientific Literature | |
| 8. | ALA2345095 | A | Ratio of AUC (0 to t) in mouse brain to AUC (0 to t) in mouse plasma | Mus musculus | 1 | ALA2331505 | cell-free format | Scientific Literature | |
| 9. | ALA2345096 | A | Ratio of Cmax in mouse brain to Cmax in mouse plasma | Mus musculus | 1 | ALA2331505 | cell-free format | Scientific Literature | |
| 10. | ALA2345097 | A | Mean residence time in mouse plasma at 50 mg/kg, po | Mus musculus | 1 | ALA2331505 | organism-based format | Scientific Literature | |
| 11. | ALA2345098 | A | Elimination half life in mouse plasma at 50 mg/kg, po | Mus musculus | 1 | ALA2331505 | organism-based format | Scientific Literature | |
| 12. | ALA2345099 | A | AUC (0 to infinity) in mouse plasma at 50 mg/kg, po | Mus musculus | 1 | ALA2331505 | organism-based format | Scientific Literature | |
| 13. | ALA2345100 | A | AUC (0 to t) in mouse plasma at 50 mg/kg, po | Mus musculus | 1 | ALA2331505 | organism-based format | Scientific Literature | |
| 14. | ALA2345101 | A | AUC (0 to infinity) in mouse brain at 50 mg/kg, po | Mus musculus | 1 | ALA2331505 | organism-based format | Scientific Literature | |
| 15. | ALA2345102 | A | AUC (0 to t) in mouse brain at 50 mg/kg, po | Mus musculus | 1 | ALA2331505 | organism-based format | Scientific Literature | |
| 16. | ALA2345103 | A | Cmax in mouse plasma at 50 mg/kg, po | Mus musculus | 1 | ALA2331505 | organism-based format | Scientific Literature | |
| 17. | ALA2345104 | A | Cmax in mouse brain at 50 mg/kg, po | Mus musculus | 1 | ALA2331505 | organism-based format | Scientific Literature | |
| 18. | ALA2345105 | A | Tmax in mouse plasma at 50 mg/kg, po | Mus musculus | 1 | ALA2331505 | organism-based format | Scientific Literature | |
| 19. | ALA2345106 | A | Tmax in mouse brain at 50 mg/kg, po | Mus musculus | 1 | ALA2331505 | organism-based format | Scientific Literature | |
| 20. | ALA2345107 | F | Inhibition of PDE5 in C57Bl6 mouse assessed as increase in electric shock-induced hippocampal cGMP level measured per mg of protein at 3 mg/kg, ip administered 30 mins prior to electric shock induction measured after 3 mins (Rvb = 0.46 0.0385 pmol) | Mus musculus | 1 | ALA2331505 | organism-based format | Scientific Literature |
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