Reversal of contextual fear memory deficit in APP/PS1 transgenic mouse assessed as increase in freezing behavior at 3 mg/kg/day, ip administered 3 weeks measured after 9 to 12 weeks by 2 day radial arm water maze test (Rvb = 10%)
Reversal of post synaptic dysfunction in APP/PS1 transgenic mouse assessed as increase in theta burst-induced long term potentiation at 3 mg/kg/day, ip administered 3 weeks measured after 9 to 12 weeks by 2 day radial arm water maze test (Rvb = 112.29 9.12%)
Reversal of contextual fear memory deficit in APP/PS1 transgenic mouse assessed as increase in freezing behavior at 3 mg/kg, ip after 3 weeks (Rvb = 10%)
Reversal of post synaptic dysfunction in APP/PS1 transgenic mouse hippocampal assessed as increase in theta burst-induced long term potentiation at 50 nM incubated 10 mins prior to theta burst induction measured after 2 hrs for 5 mins by electrophysiological assay (Rvb = 145.84 7.78%)
Reversal of contextual fear memory deficit in amyloid beta42-infused mouse assessed as increase in freezing behavior at 3 to 10 mg/kg, po administered immediately post electric shock measured after 24 hrs (Rvb = 10%)
Reversal of amyloid beta42-induced post synaptic dysfunction in mouse hippocampal assessed as increase in theta burst-induced long term potentiation at 50 nM incubated 10 mins prior to theta burst induction measured after 60 mins for 5 mins by electrophysiological assay (Rvb = 144.65 9.99%)
Inhibition of PDE5 in C57Bl6 mouse assessed as increase in electric shock-induced hippocampal cGMP level measured per mg of protein at 3 mg/kg, ip administered 30 mins prior to electric shock induction measured after 3 mins (Rvb = 0.46 0.0385 pmol)