# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2339803 | T | Toxicity in BALB/cByJ mouse assessed as biochemical parameters at 50 mg/kg, ip daily for 3 weeks measured 2 hrs after final injection | Mus musculus | 2 | organism-based format | Scientific Literature | ||
2. | ALA2339804 | T | Toxicity in BALB/cByJ mouse assessed as outward signs of distress at 50 mg/kg, ip daily for 3 weeks measured 2 hrs after final injection | Mus musculus | 2 | organism-based format | Scientific Literature | ||
3. | ALA2339805 | T | Toxicity in BALB/cByJ mouse assessed as outward signs of pain at 50 mg/kg, ip daily for 3 weeks measured 2 hrs after final injection | Mus musculus | 2 | organism-based format | Scientific Literature | ||
4. | ALA2339806 | B | Inhibition of glutamate-induced increase in lower band of PGAM5 in mouse HT22 cells at 125 nM after 16 hrs by Western blotting analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
5. | ALA2339807 | B | Inhibition of glutamate-induced decrease in DRP1 phosphorylation at serine 637 in mouse HT22 cells at 125 nM after 16 hrs by Western blotting analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
6. | ALA2339809 | F | Neuroprotective activity in mouse HT22 cells assessed as prevention from tBuOOH-induced oxidative cell death after 3 hrs by MTS assay | Mus musculus | 5 | cell-based format | Scientific Literature | ||
7. | ALA2339810 | F | Antioxidant activity in mouse HT22 cells assessed as upregulation of NQO1 protein expression 8 hrs by Western blotting analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
8. | ALA2339811 | F | Antioxidant activity in mouse HT22 cells assessed as upregulation of HO1 protein expression 8 hrs by Western blotting analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
9. | ALA2339812 | F | Neuroprotective activity in mouse HT22 cells assessed as reduction of glutamate-induced mitochondrial fragmentation at 250 nM after 8 hrs by Mitotracker DR staining-based fluorescence microscopic analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
10. | ALA2339813 | F | Neuroprotective activity in mouse HT22 cells assessed as reduction of glutamate-induced mitochondrial superoxide generation at 250 nM after 8 hrs by MitoSOX RED staining-based fluorescence microscopic analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
11. | ALA2340237 | F | Antioxidant activity in mouse HT22 cells assessed as upregulation of NQO1 gene expression at 250 nM after 16 hrs by qRT-PCR analysis in the absence of glutamate | Mus musculus | 3 | cell-based format | Scientific Literature | ||
12. | ALA2340238 | F | Antioxidant activity in mouse HT22 cells assessed as upregulation of HO1 gene expression at 250 nM after 16 hrs by qRT-PCR analysis in the absence of glutamate | Mus musculus | 3 | cell-based format | Scientific Literature | ||
13. | ALA2340239 | F | Antioxidant activity in mouse HT22 cells assessed as reduction in glutamate-induced upregulation of HO1 gene expression at 250 nM after 16 hrs by qRT-PCR analysis relative to untreated control | Mus musculus | 3 | cell-based format | Scientific Literature | ||
14. | ALA2340240 | F | Antioxidant activity in mouse HT22 cells assessed as reduction in glutamate-induced upregulation of NQO1 gene expression at 250 nM after 16 hrs by qRT-PCR analysis relative to glutamate-treated control | Mus musculus | 3 | cell-based format | Scientific Literature | ||
15. | ALA2340241 | F | Antioxidant activity assessed as DPPH free radical scavenging activity at 20 uM | 5 | assay format | Scientific Literature | |||
16. | ALA2340242 | F | Antioxidant activity in mouse HT22 cells assessed as prevention of glutamate-induced intracellular accumulation of free radicals at 250 nM after 8 hrs by spectrofluorometric analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
17. | ALA2340246 | F | Antioxidant activity in mouse HT22 cells assessed as prevention of glutamate-induced GSH depletion at 500 nM | Mus musculus | 3 | cell-based format | Scientific Literature | ||
18. | ALA2340248 | T | Neurotoxicity in mouse HT22 cells assessed as cell viability after 24 hrs by MTS assay | Mus musculus | 30 | cell-based format | Scientific Literature | ||
19. | ALA2340249 | A | Therapeutic index, ratio of cytotoxic TC50 for mouse HT22 cells to neuroprotective PD50 for mouse HT22 cells | Mus musculus | 30 | cell-based format | Scientific Literature | ||
20. | ALA2340250 | F | Neuroprotective activity in mouse HT22 cells assessed as prevention from glutamate-induced oxidative cell death by MTS assay | Mus musculus | 30 | cell-based format | Scientific Literature |