# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2346279 | ADME | Cytotoxicity against human HepG2 cells after 24 hrs by resazurin assay | Homo sapiens | 30 | ALA2331124 | cell-based format | Scientific Literature | |
2. | ALA2346280 | ADME | Cytotoxicity against HEK293 cells after 24 hrs by resazurin assay | Homo sapiens | 30 | ALA2331124 | cell-based format | Scientific Literature | |
3. | ALA2346281 | Functional | Antibacterial activity against glycopeptide-intermediate Staphylococcus aureus NRS 19 assessed as growth inhibition after 24 hrs by CLSI twofold serial broth microdilution method | Staphylococcus aureus | 13 | ALA2331124 | organism-based format | Scientific Literature | |
4. | ALA2346282 | Functional | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as growth inhibition after 24 hrs by CLSI twofold serial broth microdilution method | Staphylococcus aureus | 13 | ALA2331124 | organism-based format | Scientific Literature | |
5. | ALA2346283 | Functional | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as growth inhibition after 24 hrs by CLSI twofold serial broth microdilution method | Staphylococcus aureus | 13 | ALA2331124 | organism-based format | Scientific Literature | |
6. | ALA4421210 | Binding | Competitive binding affinity to full-length mouse SOX18 expressed in Sf9 cells assessed as reduction in SOX1 8- DNA binding using FAM-labelled Prox1 -DNA element at 1 to 1000 uM incubated for 5 mins in dark at room temperature, 10 mins at 37 degC and 30 mins at room temperature by fluorescence polarization assay | Mus musculus | 4 | ALA4420080 | cell-based format | Patent Bioactivity Data | |
7. | ALA4421211 | Functional | Antitumor activity against mouse 4T1.2 cells implanted in BALB/c mouse assessed as median disease latency time at 5 to 50 mg/kg/day for 10 days and measured up to 60 days after tumor inoculation | Mus musculus | 1 | ALA4420080 | organism-based format | Patent Bioactivity Data | |
8. | ALA4421212 | Functional | Antitumor activity against mouse 4T1.2 cells implanted in BALB/c mouse assessed as median disease latency time at 25 mg/kg/day for 10 days (Rvb =33 days) | Mus musculus | 2 | ALA4420080 | organism-based format | Patent Bioactivity Data | |
9. | ALA4421213 | Binding | Competitive binding affinity to full-length mouse SOX18 expressed in Sf9 cells assessed as reduction in SOX1 8- DNA binding using FAM-labelled Prox1 -DNA element incubated for 5 mins in dark at room temperature, 10 mins at 37 degC and 30 mins at room temperature by fluorescence polarization assay | Mus musculus | 12 | ALA4420080 | cell-based format | Patent Bioactivity Data | |
10. | ALA4421214 | Physicochemical | Critical micellar concentration of the compound | 12 | ALA4420080 | small-molecule physicochemical format | Patent Bioactivity Data | ||
11. | ALA4421215 | Binding | Inhibition of mouse SOX18 expressed in African green monkey COS7 cells assessed as reduction in SOX18 transcriptional activity by luciferase reporter gene assay | Mus musculus | 8 | ALA4420080 | cell-based format | Patent Bioactivity Data | |
12. | ALA4421216 | ADME | Cytotoxicity in African green monkey COS7 cells assessed as reduction in cell viability incubated for 24 hrs by Alamar blue dye based assay | Chlorocebus aethiops | 10 | ALA4420080 | cell-based format | Patent Bioactivity Data | |
13. | ALA4421221 | Binding | Inhibition of human adenosine A1 receptor at 10 uM relative to control | Homo sapiens | 1 | ALA4420080 | single protein format | Patent Bioactivity Data | |
14. | ALA4421222 | Binding | Inhibition of human adenosine A2A receptor at 10 uM relative to control | Homo sapiens | 1 | ALA4420080 | single protein format | Patent Bioactivity Data | |
15. | ALA4421223 | Binding | Inhibition of rat adrenergic alpha1A receptor at 10 uM relative to control | Rattus norvegicus | 1 | ALA4420080 | single protein format | Patent Bioactivity Data | |
16. | ALA4421224 | Binding | Inhibition of rat adrenergic alpha1B receptor at 10 uM relative to control | Rattus norvegicus | 1 | ALA4420080 | single protein format | Patent Bioactivity Data | |
17. | ALA4421225 | Binding | Inhibition of human adrenergic alpha2A receptor at 10 uM relative to control | Homo sapiens | 1 | ALA4420080 | single protein format | Patent Bioactivity Data | |
18. | ALA4421226 | Binding | Inhibition of human adrenergic beta1 receptor at 10 uM relative to control | Homo sapiens | 1 | ALA4420080 | single protein format | Patent Bioactivity Data | |
19. | ALA4421227 | Binding | Inhibition of human adrenergic beta2 receptor at 10 uM relative to control | Homo sapiens | 1 | ALA4420080 | single protein format | Patent Bioactivity Data | |
20. | ALA4421228 | Binding | Inhibition of human CB1 receptor at 10 uM relative to control | Homo sapiens | 1 | ALA4420080 | single protein format | Patent Bioactivity Data |