# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2344861 | F | Antiinflammatory activity in DSS-induced C57Bl/6 mouse colitis model assessed as inhibition IL-1beta level in colonic homogenate at 400 mg/kg/day administered intragastrically for 7 days | Mus musculus | 2 | organism-based format | Scientific Literature | ||
2. | ALA2344862 | F | Antiinflammatory activity in DSS-induced C57Bl/6 mouse colitis model assessed as inhibition MPO activity in colonic homogenate at 400 mg/kg/day administered intragastrically for 7 days | Mus musculus | 2 | organism-based format | Scientific Literature | ||
3. | ALA2344863 | F | Increase in ROS production in LPS-stimulated mouse CMT93 cells at 10 uM preincubated for 30 mins before LPS-challenge measured after 24 hrs post challenge by DCFDA fluorescence assay in presence of PPAR-gamma antagonist PD68235 | Mus musculus | 1 | cell-based format | Scientific Literature | ||
4. | ALA2344864 | F | Increase in ROS production in LPS-stimulated mouse CMT93 cells at 10 uM preincubated for 30 mins before LPS-challenge measured after 24 hrs post challenge by DCFDA fluorescence assay in presence of alpha-tocopherol | Mus musculus | 1 | cell-based format | Scientific Literature | ||
5. | ALA2344865 | F | Increase in ROS production in mouse CMT93 cells at 10 uM measured after 30 mins by DCFDA fluorescence assay (Rvb = 2.64 %) | Mus musculus | 1 | cell-based format | Scientific Literature | ||
6. | ALA2344866 | F | Increase in ROS production in LPS-stimulated mouse CMT93 cells at 10 uM preincubated for 30 mins before LPS-challenge measured after 30 mins post challenge by DCFDA fluorescence assay (Rvb = 2.64 %) | Mus musculus | 1 | cell-based format | Scientific Literature | ||
7. | ALA2344867 | B | Induction of PPAR-gamma promoter activity in LPS-stimulated mouse CMT93 cells at 10 uM preincubated for 30 mins before LPS-challenge measured after 6 hrs post challenge by luciferase reporter gene assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
8. | ALA2344868 | B | Induction of PPAR-gamma promoter activity in mouse CMT93 cells at 10 uM by luciferase reporter gene assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
9. | ALA2344869 | F | Antiinflammatory activity in human macrophages assessed as inhibition of LPS-induced increase in IL8 level at 10 uM preincubated for 30 mins before LPS-challenge measured after 24 hrs post challenge by ELISA in presence of PPAR-gamma antagonist PD68235 | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA2344870 | F | Antiinflammatory activity in human macrophages assessed as inhibition of LPS-induced increase in TNFalpha mRNA transcript at 10 uM preincubated for 30 mins before LPS-challenge measured after 24 hrs post challenge by quantitative PCR analysis in presence of PPAR-gamma antagonist PD68235 | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA2344872 | F | Increase in PPAR-gamma mRNA transcript level in human macrophages at 10 uM by quantitative PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
12. | ALA2344873 | B | Inhibition of LPS-induced p65 NF-kappaB activation in mouse CMT93 cells assessed as inhibition of in COX-2 expression at 10 uM preincubated for 30 mins before LPS-challenge measured after 6 hrs post challenge by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
13. | ALA2344874 | B | Inhibition of LPS-induced p65 NF-kappaB promoter activation in mouse CMT93 cells at 10 uM preincubated for 30 mins before LPS-challenge measured after 6 hrs post challenge by luciferase reporter gene assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
14. | ALA2344875 | B | Inhibition of LPS-induced p65 NF-kappaB activation in mouse CMT93 cells assessed as inhibition of in IkBalpha degradation at 10 uM preincubated for 30 mins before LPS-challenge measured after 6 hrs post challenge by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
15. | ALA2342514 | F | Antiinflammatory activity in human macrophages assessed as inhibition of LPS-induced IL8 mRNA transcript accumulation at 10 uM preincubated for 30 mins before LPS-challenge measured after 24 hrs post challenge by quantitative PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
16. | ALA2342515 | F | Antiinflammatory activity in human macrophages assessed as inhibition of LPS-induced TNFalpha mRNA transcript accumulation at 10 uM preincubated for 30 mins before LPS-challenge measured after 24 hrs post challenge by quantitative PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA2342516 | F | Antiinflammatory activity in human macrophages assessed as inhibition of LPS-induced IL8 release at 10 '-3 uM preincubated for 30 mins before LPS-challenge measured after 24 hrs post challenge by ELISA (Rvb = 7.86 +/-0.17 ng/ml) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
18. | ALA2342517 | F | Antiinflammatory activity in human macrophages assessed as inhibition of LPS-induced IL8 release at 10 '-2 uM preincubated for 30 mins before LPS-challenge measured after 24 hrs post challenge by ELISA (Rvb = 7.86 +/-0.17 ng/ml) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
19. | ALA2342518 | F | Antiinflammatory activity in human macrophages assessed as inhibition of LPS-induced IL8 release at 1 uM preincubated for 30 mins before LPS-challenge measured after 24 hrs post challenge by ELISA (Rvb = 7.86 +/-0.17 ng/ml) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
20. | ALA2342519 | F | Antiinflammatory activity in human macrophages assessed as inhibition of LPS-induced IL8 release at 5 uM preincubated for 30 mins before LPS-challenge measured after 24 hrs post challenge by ELISA (Rvb = 7.86 +/-0.17 ng/ml) | Homo sapiens | 2 | cell-based format | Scientific Literature |