# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2340615 | B | Selectivity ratio of IC50 for human DHFR to Candida glabrata DHFR | 11 | assay format | Scientific Literature | |||
2. | ALA2340616 | B | Inhibition of human DHFR | Homo sapiens | 11 | single protein format | Scientific Literature | ||
3. | ALA2340617 | B | Selectivity ratio of IC50 for human DHFR to Candida albicans DHFR | 11 | assay format | Scientific Literature | |||
4. | ALA2340618 | B | Inhibition of Candida glabrata DHFR | Nakaseomyces glabratus | 11 | assay format | Scientific Literature | ||
5. | ALA2340620 | B | Inhibition of Candida albicans DHFR | Candida albicans | 11 | single protein format | Scientific Literature | ||
6. | ALA3530563 | B | Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumption | Staphylococcus aureus | 9 | single protein format | Scientific Literature | ||
7. | ALA3530564 | F | Antimicrobial activity against Staphylococcus aureus | Staphylococcus aureus | 8 | organism-based format | Scientific Literature | ||
8. | ALA3530565 | P | Kinetic solubility of the compound | 6 | small-molecule physicochemical format | Scientific Literature | |||
9. | ALA3530566 | A | Stability in mouse liver microsomes assessed as parent compound remaining at 5 ug/ml after 1 hr at 37 degC by reverse phase HPLC method | Mus musculus | 4 | assay format | Scientific Literature | ||
10. | ALA3530567 | A | Half life in mouse liver microsomes at 5 ug/ml at 37 degC by reverse phase HPLC method | Mus musculus | 5 | assay format | Scientific Literature | ||
11. | ALA3530568 | A | Drug metabolism in mouse liver microsomes assessed as pyridyl-N-oxidation at 5 ug/ml after 1 hr at 37 degC by reverse phase HPLC method | Mus musculus | 4 | assay format | Scientific Literature | ||
12. | ALA3530569 | A | Drug metabolism in mouse liver microsomes assessed as demethylation at 5 ug/ml after 1 hr at 37 degC by reverse phase HPLC method | Mus musculus | 4 | assay format | Scientific Literature | ||
13. | ALA3530752 | A | Drug metabolism in mouse liver microsomes assessed as oxidation on pyrimidinyl substructure at 5 ug/ml after 1 hr at 37 degC by reverse phase HPLC method | Mus musculus | 4 | assay format | Scientific Literature | ||
14. | ALA3530753 | A | Drug metabolism in mouse liver microsomes assessed as bis-oxidation at 5 ug/ml after 1 hr at 37 degC by reverse phase HPLC method | Mus musculus | 4 | assay format | Scientific Literature | ||
15. | ALA3530754 | A | Stability in pH 1.2 simulated gastric fluid at 5 ug/ml after 24 hrs at 37 degC by reverse phase HPLC method | 4 | tissue-based format | Scientific Literature | |||
16. | ALA3530755 | P | Stability in water at 5 ug/ml after 24 hrs at 37 degC by reverse phase HPLC method | 4 | small-molecule physicochemical format | Scientific Literature | |||
17. | ALA3529131 | A | Stability in pH 7.4 simulated intestinal fluid at 5 ug/ml after 24 hrs at 37 degC by reverse phase HPLC method | 4 | assay format | Scientific Literature | |||
18. | ALA3529333 | A | Drug metabolism in mouse liver microsomes assessed as 3-(4-(2,4-diamino-6-methylpyrimidin-5-yl)but-3-yn-2-yl)-5-(pyridin-4-yl)phenol formation at 10 ug/ml by LC-MS/MS method | Mus musculus | 1 | assay format | Scientific Literature | ||
19. | ALA3529334 | A | Drug metabolism in mouse liver microsomes assessed as 4-(3-(4-(2,4-diamino-6-methylpyrimidin-5-yl)but-3-yn-2-yl)-5-methoxyphenyl)pyridine 1-oxide at 10 ug/ml by LC-MS/MS method | Mus musculus | 1 | assay format | Scientific Literature | ||
20. | ALA3705794 | B | Enzyme Inhibition Assay: Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureus and S. pyogenes inhibition, and evaluated for mammalian cell toxicity. | Staphylococcus aureus | 15 | single protein format | BindingDB Database |