| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2340162 | B | Binding affinity to Candida glabrata DHFR at 1 mM incubated for 2 hrs by crystallographic analysis in presence of 1 mM NADPH | Nakaseomyces glabratus | 4 | assay format | Scientific Literature | ||
| 2. | ALA2340614 | B | Binding affinity to Candida albicans DHFR at 1 mM incubated for 2 hrs by crystallographic analysis in presence of 1 mM NADPH | Candida albicans | 3 | single protein format | Scientific Literature | ||
| 3. | ALA2340615 | B | Selectivity ratio of IC50 for human DHFR to Candida glabrata DHFR | 11 | assay format | Scientific Literature | |||
| 4. | ALA2340616 | B | Inhibition of human DHFR | Homo sapiens | 11 | single protein format | Scientific Literature | ||
| 5. | ALA2340617 | B | Selectivity ratio of IC50 for human DHFR to Candida albicans DHFR | 11 | assay format | Scientific Literature | |||
| 6. | ALA2340618 | B | Inhibition of Candida glabrata DHFR | Nakaseomyces glabratus | 11 | assay format | Scientific Literature | ||
| 7. | ALA2340620 | B | Inhibition of Candida albicans DHFR | Candida albicans | 11 | single protein format | Scientific Literature | ||
| 8. | ALA3227825 | B | Inhibition of methicillin-resistant Staphylococcus aureus DHFR | Staphylococcus aureus | 4 | single protein format | Scientific Literature | ||
| 9. | ALA3227826 | B | Inhibition of methicillin-resistant Staphylococcus aureus DHFR F98Y mutant | Staphylococcus aureus | 4 | assay format | Scientific Literature | ||
| 10. | ALA3227827 | F | Antibacterial activity against methicillin-resistant Staphylococcus aureus | Staphylococcus aureus | 4 | organism-based format | Scientific Literature | ||
| 11. | ALA3227828 | F | Antibacterial activity against Bactrim-resistant Staphylococcus aureus | Staphylococcus aureus | 2 | organism-based format | Scientific Literature | ||
| 12. | ALA3227830 | F | Ratio of TMP MIC to compound MIC for methicillin-resistant Staphylococcus aureus | Staphylococcus aureus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA3226049 | F | Ratio of TMP MIC to compound MIC for Bactrim-resistant Staphylococcus aureus | Staphylococcus aureus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA3239993 | F | Antifungal activity against Candida glabrata SC5314 after 24 hrs by Alamar Blue assay | Nakaseomyces glabratus | 19 | organism-based format | Scientific Literature | ||
| 15. | ALA3239994 | F | Antifungal activity against Candida albicans NCCLS84 after 24 hrs by XTT assay | Candida albicans | 18 | organism-based format | Scientific Literature | ||
| 16. | ALA3239998 | F | Antifungal activity against Candida albicans NCCLS84 after 24 hrs by XTT assay in presence of 0.01% Triton X-100 | Candida albicans | 2 | organism-based format | Scientific Literature | ||
| 17. | ALA3530563 | B | Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumption | Staphylococcus aureus | 9 | single protein format | Scientific Literature | ||
| 18. | ALA3530564 | F | Antimicrobial activity against Staphylococcus aureus | Staphylococcus aureus | 8 | organism-based format | Scientific Literature | ||
| 19. | ALA3530565 | P | Kinetic solubility of the compound | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 20. | ALA3530566 | A | Stability in mouse liver microsomes assessed as parent compound remaining at 5 ug/ml after 1 hr at 37 degC by reverse phase HPLC method | Mus musculus | 4 | assay format | Scientific Literature |
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