Inhibition of interleukin 1 beta-induced glycosaminoglycan release in bovine articular cartilage of metacarpophalangeal joints of feet treated 48 hrs after interleukin 1beta-challenge by DMB colorimetric assay
Antiinflammatory activity in Sprague-Dawley/Wistar osteoarthritis model rat assessed as decrease in monoiodoacetate-induced hyperalgesia at 20 mg/kg, po bid for 14 days administered from day of monoiodoacetate-challenge followed by additional compound treatment after 30 mins measured 15 to 21 days post monoiodoacetate challenge by paw pressure test (Rvb = 30.4 +/- 3.1 g)
Antiinflammatory activity in Sprague-Dawley/Wistar osteoarthritis model rat assessed as decrease in monoiodoacetate-induced hyperalgesia at 20 mg/kg, po bid for 14 days administered from day of monoiodoacetate-challenge measured 15 to 21 days post monoiodoacetate challenge post by paw pressure test (Rvb = 32.6 +/- 2.9 g)
Antiinflammatory activity in Sprague-Dawley/Wistar rat assessed as decrease in carrageenan-induced paw edema at 10 mg/kg, po administered 3 hrs 30 mins after carrageenan-challenge measured after 60 mins (Rvb = 2.48 +/- 0.06 mL)
Antiinflammatory activity in Sprague-Dawley/Wistar rat assessed as decrease in carrageenan-induced paw edema at 20 mg/kg, po administered 3 hrs 30 mins after carrageenan-challenge measured after 60 mins (Rvb = 2.48 +/- 0.06 mL)
Antiinflammatory activity in Sprague-Dawley/Wistar rat assessed as decrease in carrageenan-induced hyperalgesia at 10 mg/kg, po administered 4 hrs after carrageenan-challenge measured after 120 mins (Rvb = 31.4 +/- 3.7 g)
Antiinflammatory activity in Sprague-Dawley/Wistar rat assessed as decrease in carrageenan-induced hyperalgesia at 10 mg/kg, po administered 4 hrs after carrageenan-challenge measured after 60 mins (Rvb = 33.9 +/- 3.7 g)
Antiinflammatory activity in Sprague-Dawley/Wistar rat assessed as decrease in carrageenan-induced hyperalgesia at 10 mg/kg, po administered 4 hrs after carrageenan-challenge measured after 30 mins (Rvb = 34.8 +/- 3.0 g)
Antiinflammatory activity in Sprague-Dawley/Wistar rat assessed as decrease in carrageenan-induced hyperalgesia at 20 mg/kg, po administered 4 hrs after carrageenan-challenge measured after 120 mins (Rvb = 31.4 +/- 3.7 g)
Antiinflammatory activity in Sprague-Dawley/Wistar rat assessed as decrease in carrageenan-induced hyperalgesia at 20 mg/kg, po administered 4 hrs after carrageenan-challenge measured after 60 mins (Rvb = 33.9 +/- 3.7 g)
Antiinflammatory activity in Sprague-Dawley/Wistar rat assessed as decrease in carrageenan-induced hyperalgesia at 20 mg/kg, po administered 4 hrs after carrageenan-challenge measured after 30 mins (Rvb = 34.8 +/- 3.0 g)
Antinociceptive activity in po dosed Swiss albino mouse assessed as reduction in number of acetic acid-induced writhing counted 5 mins after acetic acid challenge counted for 10 mins
Vasorelaxant activity in Wistar rat endothelium-removed thoracic aortic rings assessed as reduction of KCl-induced vasoconstriction at 0.001 uM to 10 uM treated after KCl-challenge in presence of guanylate cyclase inhibitor 1H-[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one
Vasorelaxant activity in Wistar rat endothelium-removed thoracic aortic rings assessed as reduction of KCl-induced vasoconstriction treated after KCl-challenge
Vasorelaxant activity in Wistar rat endothelium-removed thoracic aortic rings assessed as reduction of KCl-induced vasoconstriction at 0.001 uM to 10 uM treated after KCl-challenge relative to control