#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA2346433	F	Antiinflammatory activity in Sprague-Dawley/Wistar rat assessed as decrease in carrageenan-induced paw edema at 20 mg/kg, po administered 3 hrs 30 mins after carrageenan-challenge measured after 60 mins (Rvb = 2.48 +/- 0.06 mL)	Rattus norvegicus	10		organism-based format	Scientific Literature
2.	ALA2339166	F	Antiinflammatory activity in Sprague-Dawley/Wistar rat assessed as decrease in carrageenan-induced hyperalgesia at 20 mg/kg, po administered 4 hrs after carrageenan-challenge measured after 120 mins (Rvb = 31.4 +/- 3.7 g)	Rattus norvegicus	10		organism-based format	Scientific Literature
3.	ALA2339167	F	Antiinflammatory activity in Sprague-Dawley/Wistar rat assessed as decrease in carrageenan-induced hyperalgesia at 20 mg/kg, po administered 4 hrs after carrageenan-challenge measured after 60 mins (Rvb = 33.9 +/- 3.7 g)	Rattus norvegicus	10		organism-based format	Scientific Literature
4.	ALA2339168	F	Antiinflammatory activity in Sprague-Dawley/Wistar rat assessed as decrease in carrageenan-induced hyperalgesia at 20 mg/kg, po administered 4 hrs after carrageenan-challenge measured after 30 mins (Rvb = 34.8 +/- 3.0 g)	Rattus norvegicus	10		organism-based format	Scientific Literature
5.	ALA2339169	F	Antinociceptive activity in po dosed Swiss albino mouse assessed as reduction in number of acetic acid-induced writhing counted 5 mins after acetic acid challenge counted for 10 mins	Mus musculus	11		organism-based format	Scientific Literature
6.	ALA2339170	F	Vasorelaxant activity in Wistar rat endothelium-removed thoracic aortic rings assessed as reduction of KCl-induced vasoconstriction at 0.001 uM to 10 uM treated after KCl-challenge in presence of guanylate cyclase inhibitor 1H-[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one	Rattus norvegicus	5		tissue-based format	Scientific Literature
7.	ALA2339171	F	Vasorelaxant activity in Wistar rat endothelium-removed thoracic aortic rings assessed as reduction of KCl-induced vasoconstriction treated after KCl-challenge	Rattus norvegicus	6		tissue-based format	Scientific Literature
8.	ALA2339172	F	Vasorelaxant activity in Wistar rat endothelium-removed thoracic aortic rings assessed as reduction of KCl-induced vasoconstriction at 0.001 uM to 10 uM treated after KCl-challenge relative to control	Rattus norvegicus	15		tissue-based format	Scientific Literature
9.	ALA2339173	B	Selectivity index, ratio of IC50 for COX1 in mouse J774 cells to IC50 for COX1 in mouse J774 cells	Mus musculus	14		cell-based format	Scientific Literature
10.	ALA2339174	B	Inhibition of Escherichia coli lipopolysaccharide-induced COX2 activity in mouse J774 cells assessed as decrease in PGE2 levels after 24 hrs by RIA	Mus musculus	14		cell-based format	Scientific Literature
11.	ALA2339175	B	Inhibition of arachidonic acid-induced COX1 activity in mouse J774 cells assessed as decrease in PGE2 levels incubated for 15 mins prior to arachidonic acid-challenge measured after 30 mins by RIA	Mus musculus	14		cell-based format	Scientific Literature
12.	ALA3880990	B	Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as decrease in PGE2 production at 10 uM preincubated for 15 mins followed by substrate addition measured after 30 mins by radioimmunoassay relative to control	Mus musculus	52		cell-based format	Patent Bioactivity Data
13.	ALA3880991	B	Inhibition of COX2 in Escherichia coli LPS-stimulated mouse J774 cells using arachidonic acid as substrate assessed as decrease in PGE2 production preincubated for 15 mins followed by substrate addition measured after 30 mins by radioimmunoassay	Mus musculus	52		cell-based format	Patent Bioactivity Data
14.	ALA3880992	F	Vasorelaxing effect in Wistar rat thoracic aorta ring assessed as reduction of KCl-induced contractile tone at 10 uM relative to KCl	Rattus norvegicus	29		assay format	Patent Bioactivity Data
15.	ALA3880993	F	Vasorelaxing effect in Wistar rat thoracic aorta ring assessed as reduction of KCl-induced contractile tone	Rattus norvegicus	29		assay format	Patent Bioactivity Data
16.	ALA3880996	F	Vasorelaxing effect in Wistar rat thoracic aorta ring assessed as reduction of KCl-induced contractile tone at 10 uM in presence of guanylate cyclase inhibitor ODQ1	Rattus norvegicus	28		assay format	Patent Bioactivity Data
17.	ALA3887378	B	In Vitro Inhibition Assay: The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), penicillin (100 ug/mL), streptomycin (100 ug/mL), 10% of fetal bovine serum (FBS) and 1.2% of sodium pyruvate. The cells are distributed in 24-well plates at a density of 2.5x105 cells/mL or in culture dishes with a diameter of 10 cm (1x107 cells/10 mL/dish) and kept for 2 hours at 37° C. in a CO2 (5%)/O2 (95%) atmosphere. Just before the experiments, the culture medium is replaced with fresh medium without FBS to avoid interference during the radio-immunological phase and the cells are stimulated as described below.Evaluation of COX-1 Activity.The cells are pretreated with the test compounds for 15 minutes and then incubated for 30 minutes with arachidonic acid (15x10-6 m). At the end of incubation the supernatants are collected for evaluating, by means of radio-immunological assays, the amount of PGE2 produced.	Homo sapiens	47		assay format	BindingDB Database