# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2343519 | ADME | Unbound plasma concentration in beagle dog atrial fibrillation model at 10 umol.kg, iv administered as infusion for over 20 mins followed by 60 mins compound washout period | Canis lupus familiaris | 1 | ALA2331553 | organism-based format | Scientific Literature | |
2. | ALA2343520 | Functional | Cardioprotective activity in iv dosed beagle dog atrial fibrillation model assessed as reduction in heart rate administered as infusion for over 20 mins followed by 60-mins washout period by ECG analysis relative to control | Canis lupus familiaris | 1 | ALA2331553 | organism-based format | Scientific Literature | |
3. | ALA2343521 | Binding | Inhibition of dog T-type calcium channel Cav3.2 expressed in oocytes | Canis lupus familiaris | 1 | ALA2331553 | cell-based format | Scientific Literature | |
4. | ALA2343522 | ADME | Oral bioavailability in beagle dog at 3 mg/kg | Canis lupus familiaris | 1 | ALA2331553 | organism-based format | Scientific Literature | |
5. | ALA2343523 | ADME | Clearance in beagle dog at 1 mg/kg, iv | Canis lupus familiaris | 1 | ALA2331553 | organism-based format | Scientific Literature | |
6. | ALA2343524 | ADME | Unbound fraction in human plasma after 18 hrs by equilibrium dialysis method | Homo sapiens | 1 | ALA2331553 | cell-free format | Scientific Literature | |
7. | ALA2343525 | ADME | Unbound fraction in dog plasma after 18 hrs by equilibrium dialysis method | Canis lupus familiaris | 1 | ALA2331553 | cell-free format | Scientific Literature | |
8. | ALA2343526 | Physicochemical | Solubility of the compound at pH 7.4 | 1 | ALA2331553 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA2343527 | ADME | Inhibition of human recombinant CYP2C8 | Homo sapiens | 1 | ALA2331553 | single protein format | Scientific Literature | |
10. | ALA2343528 | ADME | Inhibition of human recombinant CYP1A2 | Homo sapiens | 1 | ALA2331553 | single protein format | Scientific Literature | |
11. | ALA2344002 | ADME | Inhibition of human recombinant CYP2C19 | Homo sapiens | 1 | ALA2331553 | single protein format | Scientific Literature | |
12. | ALA2344003 | ADME | Inhibition of human recombinant CYP2C9 | Homo sapiens | 1 | ALA2331553 | single protein format | Scientific Literature | |
13. | ALA2344004 | ADME | Inhibition of human recombinant CYP3A4 | Homo sapiens | 1 | ALA2331553 | single protein format | Scientific Literature | |
14. | ALA2344005 | Binding | Inhibition of human Kv4.3 channel expressed in CHO cells by IONWORKS patch clamp assay | Homo sapiens | 1 | ALA2331553 | cell-based format | Scientific Literature | |
15. | ALA2344006 | Binding | Inhibition of human IKs channel expressed in CHO cells by IONWORKS patch clamp assay | Homo sapiens | 1 | ALA2331553 | cell-based format | Scientific Literature | |
16. | ALA2344007 | Binding | Inhibition of human HCN4 channel expressed in CHO cells by IONWORKS patch clamp assay | Homo sapiens | 1 | ALA2331553 | cell-based format | Scientific Literature | |
17. | ALA2344008 | Binding | Inhibition of human Nav1.5 channel expressed in CHO cells by IONWORKS patch clamp assay | Homo sapiens | 1 | ALA2331553 | cell-based format | Scientific Literature | |
18. | ALA2344009 | Binding | Inhibition of calcium channel Cav1.2 (unknown origin) expressed in CHO cells by IONWORKS patch clamp assay | Homo sapiens | 1 | ALA2331553 | cell-based format | Scientific Literature | |
19. | ALA2344010 | ADME | Drug metabolism in human liver microsomes assessed as glutathione-adduct reactive metabolite formation at 1 mg/ml after 30 mins | Homo sapiens | 10 | ALA2331553 | microsome format | Scientific Literature | |
20. | ALA2344011 | ADME | Inhibition of human recombinant CYP2D6-mediated 7-methoxy-4(aminomethyl)-coumarine degradation | Homo sapiens | 12 | ALA2331553 | single protein format | Scientific Literature |