| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2343616 | B | Reversible inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit using Suc-LLVY-AMC as substrate incubated for 12 hrs prior to substrate addition followed by compound wash out measured after 1 hr by dialysis method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 2. | ALA2343618 | F | Induction of apoptosis in human HCT116 cells assessed as induction of PARP cleavage by Western blotting analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 3. | ALA2343619 | B | Inhibition of proteasome in human HCT116 cells assessed as accumulation of p53 by Western blotting analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 4. | ALA2343620 | F | Cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase after 24 hrs by propidium iodide staining-based flow cytometric analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 5. | ALA2343621 | F | Cytotoxicity against human HCT116 cells after 72 hrs by CCK-8 assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 6. | ALA2343623 | B | Inhibition of chymotrypsin-like activity of human 20S immunoproteasome beta 5 subunit using biotin-(CH2)4-Leu-Leu-Leu-epoxyketone as substrate at 0.3 uM incubated for 5 mins prior to substrate addition measured after 1 hr by ELISA | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 7. | ALA2343625 | B | Inhibition of chymotrypsin-like activity of human constitutive 20S proteasome beta 5 subunit using biotin-(CH2)4-Leu-Leu-Leu-epoxyketone as substrate at 0.3 uM incubated for 5 mins prior to substrate addition measured after 1 hr by ELISA | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 8. | ALA2343626 | B | Inhibition of trypsin-like activity of human 20S proteasome beta 2 subunit using Ac-RLR-AMC as substrate after 60 mins by fluorescence assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 9. | ALA2343627 | B | Inhibition of caspase-like activity of human 20S proteasome beta 1 subunit using Ac-nLPnLD-AMC as substrate after 60 mins by fluorescence assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 10. | ALA2343628 | B | Inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit using Suc-LLVY-AMC as substrate after 60 mins by fluorescence assay | Homo sapiens | 28 | single protein format | Scientific Literature | ||
| 11. | ALA2406227 | F | Cytotoxicity against human HS-Sultan cells after 72 hrs | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA2406406 | B | Inhibition of chymotrypsin-like activity of human 20S proteasome using succinyl-Leu-Leu-Val-Tyr-4-methylcoumaryl-7-amide as substrate after 60 mins by fluorescence assay | Homo sapiens | 10 | assay format | Scientific Literature | ||
| 13. | ALA2406407 | F | Cytotoxicity against human KB cells after 72 hrs | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA2406408 | F | Cytotoxicity against human HCT116 cells after 72 hrs | Homo sapiens | 3 | cell-based format | Scientific Literature |
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