| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2346011 | F | Ex-vivo SERT occupancy in Sprague-Dawley rat by autoradiographic analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA2346442 | F | Ex-vivo P2X7 receptor occupancy in sc dosed Sprague-Dawley rat brain assessed as inhibition of [3H]A804598 binding after 120 mins by autoradiographic analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA2346444 | F | Ex-vivo P2X7 receptor occupancy in Sprague-Dawley rat brain assessed as inhibition of [3H]A804598 binding at 10 mg/kg, sc by autoradiographic analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA2346446 | P | Solubility of the compound at pH 7 | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA2346448 | A | Protein binding in rat brain | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 6. | ALA2346449 | P | Solubility of the compound at pH 2 | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 7. | ALA2346450 | A | Apparent permeability from basolateral to apical side in human Caco2 cells at 1 uM after 40 mins by LC/MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA2346451 | A | Plasma protein binding in rat by equilibrium dialysis method | Rattus norvegicus | 2 | cell-free format | Scientific Literature | ||
| 9. | ALA2346452 | A | Apparent permeability from apical to basolateral side in human Caco2 cells at 1 uM after 60 mins by LC/MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA2346453 | A | Extraction ratio in mouse liver microsomes at 1 uM by LC/MS/MS analysis | Mus musculus | 2 | microsome format | Scientific Literature | ||
| 11. | ALA2346454 | A | Plasma protein binding in human by equilibrium dialysis method | Homo sapiens | 2 | cell-free format | Scientific Literature | ||
| 12. | ALA2346455 | A | Extraction ratio in human liver microsomes at 1 uM by LC/MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
| 13. | ALA2346456 | A | Extraction ratio in rat liver microsomes at 1 uM by LC/MS/MS analysis | Rattus norvegicus | 2 | microsome format | Scientific Literature | ||
| 14. | ALA2346457 | B | Inhibition of rat nACHR | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 15. | ALA2346458 | B | Inhibition of human dopamine transporter | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA2346459 | B | Inhibition of rat nACHR at 1 uM relative to control | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 17. | ALA2346460 | B | Inhibition of human dopamine transporter at 1 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA2346461 | B | Inhibition of human NK2 receptor at 1 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA2346462 | B | Antagonist activity at P2X7 receptor in human whole blood assessed as inhibition of BzATP-induced IL1beta release incubated 30 mins prior to BzATP-challenge measured after 1.5 hrs by ELISA | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 20. | ALA2346463 | B | Antagonist activity at P2X7 receptor in human PBMC assessed as inhibition of BzATP-induced IL1beta release incubated 30 mins prior to BzATP-challenge measured after 1.5 hrs by ELISA | Homo sapiens | 2 | single protein format | Scientific Literature |
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