# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2353183 | B | Inhibition of human BACE1 using MR121-labeled substrate incubated for 4 mins prior to substrate addition measured after 2 mins by spectrophotometric analysis | Homo sapiens | 37 | single protein format | Scientific Literature | ||
2. | ALA2353184 | B | Inhibition of human BACE2 using MR121-labeled substrate incubated for 4 mins prior to substrate addition measured after 2 mins by spectrophotometric analysis | Homo sapiens | 25 | single protein format | Scientific Literature | ||
3. | ALA2350602 | A | Ratio of drug uptake in brain to plasma in C57B1/6NJ mouse at 30 mg/kg, po after 4 hrs by AlphaLISA | Mus musculus | 3 | organism-based format | Scientific Literature | ||
4. | ALA2350611 | P | Dissociation constant, pKa of the compound by capillary electrophoresis | 16 | small-molecule physicochemical format | Scientific Literature | |||
5. | ALA2350614 | F | Reduction of amyloid beta40 level in C57B1/6J mouse brain at 10 mg/kg, po after 4 hrs by AlphaLISA relative to control | Mus musculus | 14 | organism-based format | Scientific Literature | ||
6. | ALA2350615 | B | Selectivity ratio of IC50 for human BACE2 to IC50 for human BACE1 | Homo sapiens | 22 | assay format | Scientific Literature | ||
7. | ALA2350616 | F | Reduction of amyloid beta40 level in C57B1/6J mouse brain at 30 mg/kg, po after 4 hrs by AlphaLISA relative to control | Mus musculus | 13 | organism-based format | Scientific Literature | ||
8. | ALA2350617 | B | Selectivity ratio of IC50 for human BACE1 to IC50 for BACE1 in HEK293 cells | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
9. | ALA2350618 | B | Inhibition of human BACE1 in HEK293 cells transfected with wild type APP assessed as reduction of amyloid beta40 level after 18 to 20 hrs by AlphaLISA technique | Homo sapiens | 36 | cell-based format | Scientific Literature |