# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2351269 | B | Inhibition of human recombinant N-terminal His6-tagged FPPS transfected in Escherichia coli BL21 (DE3) cells using GPP and [3H]-IPP as substrate incubated for 10 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
2. | ALA3091234 | B | Inhibition of human recombinant FPPS using GPP/[3H]IPP as substrate up to 10 uM incubated for 10 mins prior to substrate addition measured after 8 mins by scintillation counting analysis | Homo sapiens | 12 | single protein format | Scientific Literature | ||
3. | ALA3091236 | B | Inhibition of human recombinant FPPS using GPP/[3H]IPP as substrate incubated for 10 mins prior to substrate addition measured after 8 mins by scintillation counting analysis | Homo sapiens | 12 | single protein format | Scientific Literature | ||
4. | ALA3091237 | B | Inhibition of human recombinant FPPS using GPP/[3H]IPP as substrate incubated for 10 mins prior to substrate addition by scintillation counting analysis | Homo sapiens | 11 | single protein format | Scientific Literature | ||
5. | ALA3369319 | B | Allosteric inhibition of human recombinant FPPS using GPP and [3H]IPP as substrate incubated with enzyme for 10 mins prior to substrate addition by liquid scintillation counting analysis | Homo sapiens | 14 | single protein format | Scientific Literature | ||
6. | ALA3369324 | B | Binding affinity to human FPPS by isothermal titration colorimetry in absence of Mg2+ ions | Homo sapiens | 2 | single protein format | Scientific Literature | ||
7. | ALA3369326 | B | Inhibition of FPPS in human SH-SY5Y cells assessed as blocking of tau metabolism by measuring ratio of tau phosphorylation to total tau level at 100 nM after 24 hrs by ELISA (Rvb = 0.012 no-unit) | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
8. | ALA3369327 | A | Cytotoxicity against human SH-SY5Y cells assessed as LDH release after 48 hrs (Rvb = 0%) | Homo sapiens | 14 | cell-based format | Scientific Literature |