| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2352569 | B | Ex vivo inhibition of ADAMTS-5-mediated aggrecan degradation in IL-1-stimulated bovine cartilage explant at 30 uM | Bos taurus | 2 | single protein format | Scientific Literature | ||
| 2. | ALA2352570 | B | Ex vivo inhibition of ADAMTS-5-mediated aggrecan degradation in IL-1-stimulated bovine cartilage explant | Bos taurus | 1 | single protein format | Scientific Literature | ||
| 3. | ALA2352574 | A | Apparent permeability from apical to basolateral side of MDCK cells by transwell assay | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA2352575 | A | Intrinsic clearance in rat plasma | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA2352576 | A | Intrinsic clearance in human plasma | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA2352578 | B | Inhibition of TACE (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 7. | ALA2352580 | B | Inhibition of MMP14 (unknown origin) by FRET method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 8. | ALA2352581 | B | Inhibition of MMP3 (unknown origin) by FRET method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 9. | ALA2352582 | B | Inhibition of ADAMTS-13 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 10. | ALA2352583 | B | Inhibition of MMP2 (unknown origin) by FRET method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 11. | ALA2352584 | B | Inhibition of ADAMTS-4 (unknown origin) by FRET method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 12. | ALA2352585 | B | Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method | Homo sapiens | 27 | single protein format | Scientific Literature | ||
| 13. | ALA3106893 | P | Partition coefficient, log D of the compound at pH 7.4 by shake flask method | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 14. | ALA3106894 | B | Inhibition of TACE (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 15. | ALA3106895 | A | Permeability of the compound at 50 uM by PAMPA | 2 | assay format | Scientific Literature | |||
| 16. | ALA3106896 | B | Inhibition of human recombinant MMP-14 using fluorescence peptide matrix as substrate after 45 mins by fluorescence plate reader analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 17. | ALA3106897 | B | Inhibition of human recombinant MMP-3 using Mca-ArgProLysProValGlu-Nval-TrpArgLys(Dnp)-NH2 as substrate after 45 mins by fluorescence plate reader analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 18. | ALA3106898 | B | Inhibition of human recombinant MMP-2 using Mca-ProLeuGlyLeuDpaAlaArg-NH2 as substrate after 45 mins by fluorescence plate reader analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 19. | ALA3106899 | B | Inhibition of human recombinant ADAMTS-4 using interglobular domain peptide of aggrecan after 60 mins by FRET assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 20. | ALA3107055 | B | Inhibition of human recombinant ADAMTS-5 using interglobular domain peptide of aggrecan after 60 mins by FRET assay | Homo sapiens | 28 | single protein format | Scientific Literature |
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